Principles of Clinical Cancer Genetics: A Handbook from the Massachusetts General Hospital

Hardcover | May 14, 2010

EditorDaniel C. Chung, Daniel A. Haber

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Advances in genetics are transforming estimates of an individual's risk of developing cancer and approaches to prevention and management of cancer in those who may have increased susceptibility. Identifying and caring for patients with hereditary cancer syndromes and their family members present a complex clinical, scientific and social challenge. This textbook, by leading experts at Massachusetts General Hospital Cancer Center, highlights the current understanding of the genetics of hereditary cancers of the breast, ovary, colorectum, stomach, pancreas, kidney, skin, and endocrine organs. Practical guidelines for the use of genetic testing, cancer screening and surveillance, prophylactic surgery, and promising targeted therapeutic agents are discussed.In addition, ongoing research involving genome-wide screens to identify novel modest risk-associated genetic loci are explored, along with new approaches to the application of genetic markers in guiding therapeutic options.

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From the Publisher

Advances in genetics are transforming estimates of an individual's risk of developing cancer and approaches to prevention and management of cancer in those who may have increased susceptibility. Identifying and caring for patients with hereditary cancer syndromes and their family members present a complex clinical, scientific and socia...

From the Jacket

Advances in genetics are transforming estimates of an individual's risk of developing cancer and approaches to prevention and management of cancer in those who may have increased susceptibility. Identifying and caring for patients with hereditary cancer syndromes and their family members present a complex clinical, scientific and socia...

Format:HardcoverDimensions:237 pages, 10.98 × 8.27 × 0.27 inPublished:May 14, 2010Publisher:Springer USLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0387938443

ISBN - 13:9780387938448

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Table of Contents

Basic principles of cancer geneticsPrinciples of Cancer Genetic Counseling and Genetic Testing Genetics of Hereditary Breast CancerSurgical management of Hereditary Breast and Ovarian CancerHereditary colon cancer: Colonic Polyposis SyndromesHereditary colon cancer: Lynch Syndrome Hereditary Pancreatic CancerHereditary Diffuse Gastric CancerFamilial Renal Cell Cancers and PheochromocytomasFamilial Atypical Mole Melanoma (FAMM) SyndromeMultiple Endocrine NeoplasiaPediatric malignancies: Retinoblastoma and Wilms' tumorNeurofibromatosis and SchwannomatosisThe Hap Map project and low penetrance cancer susceptibility allelesSomatic genetic alterations and implications for targeted therapies in cancer (GIST, CML, Lung cancer)

Editorial Reviews

From the reviews:"This thorough book outlines the most common genetic contributions to cancer and reviews cancer genetics and genetic counseling as well as recent advances in genome-wide association studies (GWAS) research and personalized medicine. . a largely useful resource, particularly for students, residents, and entry-level clinicians in clinical cancer genetics." (Heather H. Wetzel, Doody's Review Service, August, 2010)