Principles of Molecular Rheumatology by George C. TsokosPrinciples of Molecular Rheumatology by George C. Tsokos

Principles of Molecular Rheumatology

EditorGeorge C. Tsokos

Paperback | November 19, 2010

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George Tsokos and a panel of authoritative clinicians and researchers synthesize the latest findings from across cell and molecular biology with the basic principles of rheumatology to create the first textbook of molecular rheumatology. These established experts describe the biochemical mechanisms by which apoptosis, cell signaling, complement, lipids, and viruses contribute to disease expression, and detail both immune and nonimmune cell function in rheumatic diseases. Their review of the major rheumatic diseases integrates the cellular, biochemical, and molecular biological mechanisms that are important in rheumatic disease pathogenesis. Path-breaking and illuminating, Principles of Molecular Rheumatology expands the envelope of clinical understanding to reveal the biological roots underlying rheumatologic disease, as well as the nature and roles of the powerful new therapeutics now emerging for its optimal treatment.
Title:Principles of Molecular RheumatologyFormat:PaperbackDimensions:555 pagesPublished:November 19, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617371823

ISBN - 13:9781617371820

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Table of Contents

Part I. Molecular Mechanisms in Rheumatic DiseasesGeneticsPeter K. GregersenVirusesAndras PerlApoptosisJohn D. Mountz, Hui-Chen Hsu, Huang-Ge Zhang, and Tong ZhouHumoral ResponseGary S. GilkesonT-Cell SignalingGary A. Koretzky and Erik J. PetersonAdhesion and Costimulatory MoleculesVassiliki A. Boussiotis, Gordon J. Freeman, and Lee M. NadlerTranscription FactorsHenry K. WongImmune ComplexesMark H. WenerComplementV. Michael HolersEicosanoids and Other Bioactive LipidsLeslie J. CroffordCollagensSergio A. JiménezPart II. Cellular Mechanisms in Rheumatic DiseasesT-LymphocytesNilamadhab Mishra and Gary M. KammerB-LymphocytesRobert F. AshmanMonocytes and MacrophagesJames M. K. Chan and Sharon M. WahlPolymorphonuclear CellsMichael H. Pillinger, Pamela B. Rosenthal, and Bruce N. CronsteinSynoviocytesDavid E. YocumChondrocytesTariq M. Haqqi, Donald D. Anthony, and Charles J. MalemudOsteoblasts and OsteoclastsStavros C. ManolagasAnimal ModelsThomas J. Lang and Charles S. ViaPart III. Pathogenesis of Rheumatic DiseasesSystemic Lupus ErythematosusStamatis-Nick C. Liossis and George C. TsokosRheumatoid ArthritisRichard M. Pope and Harris PerlmanInflammatory MyopathiesNorbert Goebels and Reinhard HohlfeldSystemic SclerosisTimothy M. WrightVasculitisJörg J. Goronzy and Cornelia M. WeyandOsteoarthritisRobin Poole and Ginette WebbOsteoporosisStavros C. ManolagasHeritable Disorders of Connective TissuePetros TsipourasPart IV. Molecular Aspects of Treatment of Rheumatic DiseasesCorticosteroidsHenry K. Wong and George C. TsokosCytotoxic DrugsDavid A. Fox and W. Joseph McCuneComplement InhibitorsSavvas C. MakridesCytokine Response ModifiersRichard E. Jones and Larry W. MorelandRestoration of Immune ToleranceWoodruff EmlenMetalloproteases and Their Modulation as Treatment in OsteoarthritisJohanne Martel-Pelletier, Ginette Tardif, Julio Fernandes, and Jean-Pierre PelletierGene TherapyRobert P. Kimberly

Editorial Reviews

"Unlike previous classical textbooks of rheumatology in which the clinical and therapeutic approaches to rheumatic disease are discussed, this one is unique in the contributors' ability to integrate the clinical approach to rheumatic disease with the latest biochemical, cellular, and molecular mechanisms at play in these disorders. This approach allows clinical rheumatologists to gain a better understanding of the cellular and molecular biology that underlies the diseases we treat and the therapeutics we use to treat these disorders.."-Doody's Health Science Book Review Journal"It contains many figures of good quality." - Journal of Endocrine Genetics"Unlike previous classical textbooks of rheumatology in which the clinical and therapeutic approaches to rheumatic disease are discussed, this one is unique in the contributors' ability to integrate the clinical approach to rheumatic disease with the latest biochemical, cellular, and molecular mechanisms at play in these disorders. This approach allows clinical rheumatologists to gain a better understanding of the cellular and molecular biology that underlies the diseases we treat and the therapeutics we use to treat these disorders." - Doody Publishing