Prion Protein

Hardcover | September 1, 2017

byGiuseppe LegnameEditorSilvia Vanni

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This thematic volume of Progress in Molecular Biology and Translational Science focuses on Prion Protein. Neurodegenerative diseases represent a health issue that in recent years has received increasing attention from the scientific community, due to their social and economic impact. In particular, prion protein is considered to be the archetype of intrinsically disordered proteins that, upon misfolding, are prone to adopt aberrant conformations. Nevertheless the molecular events underlying the onset and the progression of these diseases misfolding, spreading, plaques formation, neuronal death are still largely unknown. Accessible to students Written by leading authorities

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This thematic volume of Progress in Molecular Biology and Translational Science focuses on Prion Protein. Neurodegenerative diseases represent a health issue that in recent years has received increasing attention from the scientific community, due to their social and economic impact. In particular, prion protein is considered to be the...

Giuseppe Legname carried undergraduate and postgraduate studies in biochemistry and molecular biology at the Università degli Studi of Milan, Italy. He gained his Doctor of Philosophy (D.Phil.) degree in Biological Sciences at the University of Warwick in 1997. After a long spell in Industry where he coauthored many scientific papers a...
Format:HardcoverDimensions:300 pages, 9.41 × 7.24 × 0.98 inPublished:September 1, 2017Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0128112263

ISBN - 13:9780128112267

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Table of Contents

  1. Functions of Prion Protein
    Sophie Mouillet-Richard
  2. Copper and Prion protein
    Glenn Millhauser
  3. Cell Biology of Prion Protein
    Chiara Zurzolo and Daniela Sarnataro
  4. Structural Studies of Prion Proteins
    Janez Plavec
  5. Molecular Simulations on Wild Type and Mutant Prion Proteins
    Paolo Carloni
  6. Genetics of Prion Protein
    George A. Carlson
  7. The Prion Concept and Synthetic Prions
    Giuseppe Legname and Silvia Vanni
  8. Transgenic Mouse Models
    Abigail Diack
  9. Transmission and Replication of Prions
    Juan Maria Torres
  10. Immunology of Prion Protein and Prions
    Neil Andrew Mabbott
  11. BSE, BASE
    Cristina Casalone and Corona Cristiano
  12. Scrapie, CDW and Trasmissible Mink Encephalopathy
    Candace Mathiason
  13. Infectious and Sporadic Prion Diseases
    Richard Knight
  14. Inhereted Prion Diseases
    Bernardino Ghetti
  15. Neuropathology of Prion Diseases
    James Wilson Ironside and Diane Ritchie
  16. Structural Studies of Prions
    Holger Wille and Jesus Requena
  17. Protein Misfolding Cyclic Amplification
    Fabio Moda
  18. Biochemical Characterization of Prions
    Gianluigi Zanusso
  19. Transcriptomics and Genomics of Prion Diseases
    Giuseppe Legname and Silvia Vanni
  20. Therapeutic Approaches to Prion Diseases
    Maria Laura Bolognesi
  21. Biosafety of Prions
    Fabio Moda