Prion Protein by Giuseppe LegnamePrion Protein by Giuseppe Legname

Prion Protein

byGiuseppe LegnameEditorSilvia Vanni

Hardcover | August 21, 2017

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Prion Protein, Volume 150, the latest volume in theProgress in Molecular Biology and Translational Scienceseries, focuses on Prion Protein, a protein that is considered to be the archetype of intrinsically disordered proteins. This updated volume includes comprehensive sections on a variety of timely topics, including Functions of Prion Protein, Copper and Prion protein, Cell Biology of Prion Protein, Structural Studies of Prion Proteins, Molecular Simulations on Wild Type and Mutant Prion Proteins, Genetics of Prion Protein, The Prion Concept and Synthetic Prions, and Transgenic Mouse Models.

As neurodegenerative diseases represent a health issue that is receiving increasing attention from the scientific community due to their social and economic impact, this series is an ideal resource for the latest research in molecular biology and translational science.



  • Presents the latest volume in theProgress in Molecular Biology and Translational Scienceseries
  • Accessible to students and researcher alike
  • Written by leading authorities in the field of prion protein
Giuseppe Legname carried undergraduate and postgraduate studies in biochemistry and molecular biology at the Università degli Studi of Milan, Italy. He gained his Doctor of Philosophy (D.Phil.) degree in Biological Sciences at the University of Warwick in 1997. After a long spell in Industry where he coauthored many scientific papers a...
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Title:Prion ProteinFormat:HardcoverDimensions:516 pages, 9.41 × 7.24 × 0.98 inPublished:August 21, 2017Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0128112263

ISBN - 13:9780128112267

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Table of Contents

  1. Functions of the Prion Protein
    Théo Z. Hirsch, Séverine Martin-Lannerée and Sophie Mouillet-Richard
  2. Copper- and Zinc-Promoted Interdomain Structure in the Prion Protein: A Mechanism for Autoinhibition of the Neurotoxic N-Terminus
    Eric G.B. Evans and Glenn L. Millhauser
  3. Cell Biology of Prion Protein
    Daniela Sarnataro, Anna Pepe and Chiara Zurzolo
  4. Understanding the Effect of Disease-Related Mutations on Human Prion Protein Structure: Insights From NMR Spectroscopy
    Ivana Biljan, Gregor Ilc and Janez Plavec
  5. Structural Modeling of Human Prion Protein's Point Mutations
    Giulia Rossetti and Paolo Carloni
  6. Prion Protein and Genetic Susceptibility to Diseases Caused by Its Misfolding
    George A. Carlson
  7. The Prion Concept and Synthetic Prions
    Giuseppe Legname and Fabio Moda
  8. Gene Targeted Transgenic Mouse Models in Prion Research
    Abigail B. Diack, James D. Alibhai and Jean C. Manson
  9. Transmission and Replication of Prions
    A. Marín-Moreno, N. Fernández-Borges, J.C. Espinosa, O. Andréoletti and J.M. Torres
  10. Immunology of Prion Protein and Prions
    Neil A. Mabbott
  11. Phenotypical Variability in Bovine Spongiform Encephalopathy: Epidemiology, Pathogenesis, and Diagnosis of Classical and Atypical Forms
    Cristiano Corona, Elena V. Costassa, Barbara Iulini, Elena Bozzetta, Maria Mazza, Rosanna Desiato, Giuseppe Ru and Cristina Casalone
  12. Scrapie, CWD, and Transmissible Spongiform Encephalopathy
    Candace K. Mathiason
  13. Infectious and Sporadic Prion Diseases
    Richard Knight
  14. Neuropathology of Human Prion Diseases
    Diane L. Ritchie and James W. Ironside
  15. The Structure of the Infectious Prion Protein and Its Propagation
    Jesús R. Requena and Holger Wille
  16. Protein Misfolding Cyclic Amplification of Infectious Prions
    Fabio Moda
  17. Amplified Detection of Prions and Other Amyloids by RT-QuIC in Diagnostics and the Evaluation of Therapeutics and Disinfectants
    Byron Caughey, Christina D. Orru, Bradley R. Groveman, Andrew G. Hughson, Matteo Manca, Lynne D. Raymond, Gregory J. Raymond, Brent Race, Eri Saijo and Allison Kraus
  18. Biochemical Characterization of Prions
    Michele Fiorini, Matilde Bongianni, Salvatore Monaco and Gianluigi Zanusso
  19. Omics of Prion Diseases
    Silvia Vanni
  20. Therapeutic Approaches to Prion Diseases
    Annachiara Gandini and Maria L. Bolognesi
  21. Biosafety of Prions
    Edoardo Bistaffa, Martina Rossi, Chiara M.G. De Luca and Fabio Moda