Process Development: Fine Chemicals from Grams to Kilograms by Stan LeeProcess Development: Fine Chemicals from Grams to Kilograms by Stan Lee

Process Development: Fine Chemicals from Grams to Kilograms

byStan Lee, Graham Robinson

Paperback | July 1, 1995

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Process development bridges the gap between the laboratory synthesis of an organic compound and its industrial manufacture on a large scale. In this concise text the authors use real examples to show the problems which may be encountered in scaling up chemical syntheses and the ways in whichthese problems may be overcome. The major part of the book is devoted to genuine case histories from ICI/Zeneca Pharmaceuticals. Through a range of carefully chosen examples, the book explains how it is possible to synthesise multi-kilogram quantities of a new organic compound which have beenmade in the laboratory only on the milligram scale. A wide range of aliphatic, aromatic, and heterocyclic compounds is covered. The book will be of particular value to research chemists who are involved in the development phase of novel compounds and to advanced undergraduate and postgraduatestudents interested in the fine chemicals industry.
Stan Lee and Graham Robinson are both at Zeneca Pharmaceuticals, Macclesfield, Cheshire.
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Title:Process Development: Fine Chemicals from Grams to KilogramsFormat:PaperbackDimensions:96 pages, 9.69 × 7.44 × 0.24 inPublished:July 1, 1995Publisher:Oxford University Press

The following ISBNs are associated with this title:

ISBN - 10:0198558244

ISBN - 13:9780198558248

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Table of Contents

Introduction1. Scale up issues2. Environmental and regulatory issyes3. Fun with cephalosporins4. Thromboxane antagonists5. Homochiral thrombozane antagonists6. H2 blockers7. Development of a manufacturing route for cloprostenol sodium8. Synthesis of a potentially anti-obesity agent9. Reagents for large scale operation

Editorial Reviews

`excellent..volume'Chemistry in Britain