Process Development: Physicochemical Concepts

Paperback | December 1, 1999

byJohn Atherton, Keith Carpenter

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The Fine Chemicals industry is concerned with the manufacture of relatively small volume products by multistage manufacturing processes. Pharmaceuticals, agrochemicals, colouring materials and biocidal compounds are typical examples. Understanding the fundamental science behind thesechemical processes is of great benefit in the development of efficient, high-yielding and environmentally friendly processes. However, there are no other texts which specifically address this topic by covering the physiochemical principles underpinning the subject. This primer outlines the strategy for obtaining the requisite data, and then goes on to outline the chemical and chemical engineering concepts involved inprocess development. These include a description of pre-reaction equilibria in single and two-phase systems, factors influencing selectivity in competing reactions, mixing effects in single and two-phase reactions, the science behind workup processes, and a discussion of the principles behindscale-up.

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The Fine Chemicals industry is concerned with the manufacture of relatively small volume products by multistage manufacturing processes. Pharmaceuticals, agrochemicals, colouring materials and biocidal compounds are typical examples. Understanding the fundamental science behind thesechemical processes is of great benefit in the devel...

Dr John Atherton, Process Studies Group, Zeneca Huddersfield Works, Leeds Road, Huddersfield, HD2 1FF. Fax: 01484 486051. Email: john.atherton@hfield.zeneca.com Professor Keith Carpenter, Process Studies Group, Zeneca Huddersfield Works, Leeds Road, Huddersfield, HD2 1FF. Fax: 01484 486057.

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Format:PaperbackPublished:December 1, 1999Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0198503725

ISBN - 13:9780198503729

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Table of Contents

1. The scope of process development2. Strategy for process development3. Pre-reaction equilibria4. Competing reactions in homogeneous media5. Mixing effects in pseudo-homgeneous systems6. Equilibria in multiphase systems7. Dispersion and mass transfer in multiphase systems8. Mass-transfer and reaction in two-phase systems9. Product isolation and workup10. Scale-upIndex

Editorial Reviews

"This book [makes] invaluable reading for undergraduates with a basic knowledge of physical organic chemistry and algebra. I recommend it." James Betts in Education in Chemistry, May 2001