Progress in Medicinal Chemistry

Other | April 1, 2006

byKing, F.D., F.d. King

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The perceived lack of drug discovery productivity in recent times has led to much debate in the pharmaceutical/biotechnology industry as escalating R&D costs are not being matched by increased output. Few observers doubt that selecting the right targets, ie those which are critical to disease pathology and are 'druggable', is the best starting point for improved productivity.

The seven chapters of this volume describe recent progress towards drugs acting at a range of 'druggable' targets. One chapter addresses kinases, one covers an ion channel, two proteases are featured and three of the chapters cover G-protein coupled receptors, which has historically perhaps been the most fruitful area for medicinal chemists.

*Presents the latest research in the field of drug discovery
*Publishes on an annual basis to bring you the most innovative updates in medicinal chemistry
*Available as an online resource via ScienceDirect

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The perceived lack of drug discovery productivity in recent times has led to much debate in the pharmaceutical/biotechnology industry as escalating R&D costs are not being matched by increased output. Few observers doubt that selecting the right targets, ie those which are critical to disease pathology and are 'druggable', is the best ...

Dr Geoff Lawton has extensive experience in new medicine discovery across many therapeutic areas in both large and small companies and is a co-inventor of a marketed drug (Cilazapril). He is a former Director of Chemistry at Roche UK, and Vice-president Chemistry and Preclinical Sciences within Roche Bioscience, Palo Alto, USA. He was ...

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Format:OtherDimensions:404 pages, 1 × 1 × 1 inPublished:April 1, 2006Publisher:Elsevier ScienceLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0080462103

ISBN - 13:9780080462103

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Table of Contents

1. Finding Protein Kinase Hits Using Structural Information
2. Blunting the Swiss Army Knife
3. Peptide Deformylase Inhibitors
4. Clinically Useful Vanilloid Receptor TRPV1 Antagonists
5. Recent Medicinal Chemistry of the Histamine H3 Receptor
6. Recent Progress in Cannabinoid research
7. Oxytocin Antagonists as Potential Therapeutic Agents