Prokaryotic Gene Expression

Paperback | May 1, 1999

EditorSimon Baumberg

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Prokaryotic gene expression is not only of theoretical interest but also of highly practical significance. It has implications for other biological problems, such as developmental biology and cancer, brings insights into genetic engineering and expression systems, and has consequences forimportant aspects of applied research. For example, the molecular basis of bacterial pathogenicity has implications for new antibiotics and in crop development. Prokaryotic Gene Expression is a major review of the subject, providing up-to-date coverage as well as numerous insights by theprestigious authors. Topics covered include operons; protein recognition of sequence specific DNA- and RNA-binding sites; promoters; sigma factors, and variant tRNA polymerases; repressors and activators; post-transcriptional control and attenuation; ribonuclease activity, mRNA stability, andtranslational repression; prokaryotic DNA topology, topoisomerases, and gene expression; regulatory networks, regulatory cascades and signal transduction; phosphotransfer reactions; switch systems, transcriptional and translational modulation, methylation, and recombination mechanisms;pathogenicity, toxin regulation and virulence determinants; sporulation and genetic regulation of antibiotic production; origins of regulatory molecules, selective pressures and evolution of prokaryotic regulatory mechanisms systems. Over 1100 references to the primary literature are cited.Prokaryotic Gene Expression is a comprehensive and authoritative review of current knowledge and research in the area. It is essential reading for postgraduates and researchers in the field. Advanced undergraduates in biochemistry, molecular biology, and microbiology will also find this bookuseful.

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From the Publisher

Prokaryotic gene expression is not only of theoretical interest but also of highly practical significance. It has implications for other biological problems, such as developmental biology and cancer, brings insights into genetic engineering and expression systems, and has consequences forimportant aspects of applied research. For exa...

Simon Baumberg is at University of Leeds.
Format:PaperbackPublished:May 1, 1999Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199636036

ISBN - 13:9780199636037

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Table of Contents

1. History and overview2. Protein recognition of specific DNA and RNA bonding sites3. Promoters, sigma factors, and variant RNA polymerases4. Repressors and activators5. Post-transcriptional control6. Prokaryotic DNA topology and gene expression7. Integration of control devices: A global regulatory network in Escherichia coli.8. Two component systems9. Switch systems10. Integration of control devices I. Pathogenecity11. Integration of control devices II. Sporulation and antibiotic production12. Evolution of prokaryotic regulatory systems

Editorial Reviews

'....It is a book that should be read and not merely used for reference....If you want to understand the main mechanisms of bacterial gene regulation and to appreciate their history, breadth and detail, read this book.' Micro Biology Today