Prostaglandin Synthesis reviews the developments in the preparation and isolation of prostaglandins by synthesis, with emphasis on the more promising and significant approaches. It includes a nomenclature of prostaglandins and considers prostaglandin analogs as well as their structure-activity relationships, prostaglandin interconversions, isomeric prostaglandins, and deoxyprostaglandins.
Organized into 21 chapters, this book begins with an overview of prostaglandin biosynthesis and the potential clinical utility of prostaglandins. It then discusses the discovery of prostaglandins and the isolation of prostaglandins E and F, format for structural presentation of prostaglandins, closure of the cyclopentane ring from acyclic precursors, and conjugate addition of organometallic derivatives to alpha-substituted cyclopentenones. It explains the cyclohexane and bicyclohexane precursors, Corey's synthesis of bicyclohexane precursors, bicyclooctane and bicyclononane precursors, and approaches to synthesis of A, B, C, and D prostaglandins.
This book is a valuable resource for biochemists and others working in the field of prostaglandin biosynthesis.