Protecting Group Chemistry by Jeremy Robertson

Protecting Group Chemistry

byJeremy Robertson

Paperback | August 1, 2000

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Protecting Group Chemistry provides an overview of the general methods that are used to block the reactivity of - i.e. protect - specific functional grops thus allowing others, present within the same molecule, to be manipulated unambiguously. An introductory chapter outlines protecting groupstrategy, relevant aspects of functional group reactivity, temporary protection, and introduces the concept of protecting group devices as an aid to unifying the wide range of available methods. The rest of the book is divided on the basis of broad classes of the experimental conditions that lead tocleavage of each protecting group (acid/electrophile, base/nucleophile, oxidising or reducing agent). The treatment differs from traditional texts in that it places the emphasis on making a connection between the fundamental mechanisms of organic chemsitry - ionisation, substitution, addition,elimination, oxidation and reduction, etc. - and how a particular protecting group can best be selected in a given situation.

About The Author

Jeremy Robertson, MA DPhil, University Lecturer in Organic Chemistry and Fellow of Brasenose College, Oxford.
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Title:Protecting Group ChemistryFormat:PaperbackDimensions:96 pages, 9.69 × 7.44 × 0.31 inPublished:August 1, 2000Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0198502753

ISBN - 13:9780198502753

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Table of Contents

1. Introduction2. Acid-labile protecting groups3. Nucleophile/base-labile protecting groups4. Redox deprotection