Protein Engineering for Therapeutics, Part A

Other | February 23, 2012

byK. Dane Wittrup, K. Dane Wittrup, Gregory L. Verdine

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This volume of Methods in Enzymology looks at Protein Engineering for Therapeutics. The chapters provide an invaluable resource for academics, researchers and students alike. With an international board of authors, this volume is split into sections that cover subjects such as Antibodies, Protein conjugates, Peptides, Enzymes and Scaffolds



  • Chapters provide an invaluable resource for academics, researchers and students alike
  • Iinternational board of authors
  • This volume is split into sections that cover subjects such as Antibodies, Protein conjugates, Peptides, Enzymes and Scaffolds

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This volume of Methods in Enzymology looks at Protein Engineering for Therapeutics. The chapters provide an invaluable resource for academics, researchers and students alike. With an international board of authors, this volume is split into sections that cover subjects such as Antibodies, Protein conjugates, Peptides, Enzymes and Scaff...

Format:OtherDimensions:392 pages, 1 × 1 × 1 inPublished:February 23, 2012Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0123914744

ISBN - 13:9780123914743

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Table of Contents

  1. Simplified Synthetic Antibody Libraries
  2. Generation of Dual Variable Domain Immunoglobulin Molecules for Dual-specific Targeting
  3. Discovery of internalizing antibodies to tumor antigens from phage libraries
  4. Optimizing properties of anti-receptor antibodies using kinetic computational models and experiments
  5. Cell-specific siRNA delivery by peptides and antibodies
  6. Conjugation of Anticancer Drugs Through Endogenous Monoclonal Antibody Cysteine Residues
  7. Building and characterizing antibody-targeted lipidic nanotherapeutics
  8. Cell-Targeting Fusion Constructs Containing Recombinant Gelonin
  9. Stapled Peptides for Intracellular Drug Targets
  10. Mapping of vascular zip codes by phage display
  11. Engineering cyclic peptide toxins
  12. Peptide Discovery using Bacterial Display and Flow Cytometry
  13. Oral enzyme therapy for celiac sprue
  14. Rational Design and Evaluation of Mammalian Ribonuclease Cytotoxins
  15. Engineering Reduced-Immunogenicity Enzymes for Amino Acid Depletion Therapy in Cancer
  16. Designed Ankyrin Repeat Proteins (DARPins): From research to therapy
  17. Target-binding proteins based on the tenth human fibronectin type III domain (10Fn3)
  18. Anticalins: small engineered binding proteins based on the lipocalin scaffold
  19. T Cell Receptor Engineering
  20. Engineering Knottins as Novel Binding Agents
  21. Re-Engineering Biopharmaceuticals for Targeted Delivery Across the Blood-Brain Barrier
  22. Practical Theoretic Guidance for the Design of Tumor Targeting Agents
  23. Fusions of elastin-like polypeptides to pharmaceutical proteins
  24. Engineering and Identifying Supercharged Proteins for Macromolecule Delivery into Mammalian Cells