Protein Kinase C in Cancer Signaling and Therapy by Marcelo G. KazanietzProtein Kinase C in Cancer Signaling and Therapy by Marcelo G. Kazanietz

Protein Kinase C in Cancer Signaling and Therapy

EditorMarcelo G. Kazanietz

Paperback | September 7, 2012

Pricing and Purchase Info

$420.26 online 
$466.95 list price save 9%
Earn 2,101 plum® points

Prices and offers may vary in store


In stock online

Ships free on orders over $25

Not available in stores


Protein kinase C (PKC), a family of serine-threonine kinases, rocketed to the forefront of the cancer research field in the early 1980's with its identification as an effector of phorbol esters, natural products with tumor promoting activity. Phorbol esters had long been of interest to the cancer research field due to early studies in the mouse skin carcinogenesis model, which showed that prolonged topical application of phorbol esters promoted the formation of skin tumors on mice previously treated with mutagenic agents. Research in the last years has established key roles for PKC isozymes in the control of cell proliferation, migration, adhesion, and malignant transformation. In addition, there is a large body of evidence linking PKC to invasion and cancer cell metastasis. Moreover, it is now well established that the expression of PKC isozymes is altered in various types of cancers. More importantly, small molecule inhibitors have been developed with significant anti-cancer activity. The relevance of PKC isozymes in cancer signaling is therefore remarkable.This book will have 4 sections. There will be 23 chapters. Each section will have a brief introduction by an expert in the field (~ 1-2 pages).
Title:Protein Kinase C in Cancer Signaling and TherapyFormat:PaperbackDimensions:346 pagesPublished:September 7, 2012Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617796913

ISBN - 13:9781617796913

Look for similar items by category:


Table of Contents

Part I Regulation of PKC isozyme function: from genes to biochemistryProtein Kinase C in Cancer Signaling and Therapy, Introduction and Historical Perspective - Alex TokerRegulation of conventional and novel protein kinase C isozymes by phosphorylation and lipids - Alexandra Newton Phorbol esters and diacylglycerol: the PKC activators - Peter M. BlumbergDiacylglycerol signaling: the C1 domain, generation of DAG and termination of signals - Isabel MeridaRegulation of PKC by protein-protein interactions in cancer - Daria Mochly-RosenPart II PKC isozymes in the control of cell functionIntroduction: PKC isozymes in the control of cell function - Chris LarssonRegulation and function of protein kinase D signaling - Enrique RozengurtPKC and control of the cell cycle - Jennifer BlackPKC and the control of apoptosis - Mary ReylandAtypical PKCs, NF-kB and inflammation - Maria Teresa Diaz-Meco and Jorge MoscatPart IIIPKC isozymes in cancer Introduction. PKC isozymes in cancer - Marcelo G. Kazanietz PKC, p53, and DNA damage - Kiyotsugu Yoshida PKCs as mediators of the Hedgehog and Wnt pathways - Natalia RioboPKC-PKD interplay in cancer - Jane WangTransgenic mouse models to investigate functional specificity of protein kinase C isoforms in the development of squamous cell carcinoma, a non-melanoma human skin cancer - Ajit VermaPKC isozymes and skin cancer - Mitch DenningPKC isozymes and breast cancer - Sofia MerajverPKC and prostate cancer - Jeewon Kim and Marcelo Kazanietz.PKC and lung cancer - Lei XiaoPart IVPKC isozymes as targets for cancer therapyIntroduction. PKC isozymes as targets for cancer therapy - Patricia LorenzoPKC and resistance to chemotherapeutic agents - Alakhananda BasuPKCd as a target for chemotherapeutic drugs - Chaya BrodieAtypical PKCs as targets for cancer therapy - Alan Fields