Protein Kinase Functions

Paperback | August 1, 2000

EditorJames Woodgett

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Since the publication of Protein Kinases in 1994 many novel protein kinases have been discovered, but perhaps more importantly there have been dramatic advances in our understanding of the cellular functions of this remarkably diverse class of proteins. Protein Kinase Functions is not just anupdate of the previous edition but provides a new focus on the context and function of protein kinases, thus reflecting the recent advances in kinase biology. Chapters on genetic approaches to protein kinase functions, the MAP kinase pathway, and cyclin-dependent kinases have been completely updatedand new topics covered in depth are: phosphatidylinositol 3-kinase signalling, JAK-STAT signalling, suppression of tyrosine kinases by the SOCS family proteins, the TGFss superfamily, and the involvement of protein kinases in response to DNA damage. Throughout, emphasis is placed not on individualkinases, but on the functional aspects of the whole system and the relationship between processes and molecules. It is the aim of Protein Kinase Functions to enable the reader to assimilate, compare, and integrate the molecular machinery used by cells to co-ordinate and respond to theirenvironments.

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From the Publisher

Since the publication of Protein Kinases in 1994 many novel protein kinases have been discovered, but perhaps more importantly there have been dramatic advances in our understanding of the cellular functions of this remarkably diverse class of proteins. Protein Kinase Functions is not just anupdate of the previous edition but provides ...

James Woodgett is at Ontario Cancer Institute, University of Toronto.
Format:PaperbackPublished:August 1, 2000Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199637709

ISBN - 13:9780199637706

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Table of Contents

Phosphatidylinositol 3-kinase signalling: a tale of two kinase activitiesMammalian MAP kinase pathwaysGenetic approaches to protein kinase function in lower eukaryotesSpecificity in JAK-STAT signallingOn the road to destruction: suppression of protein tyrosine kinaseCyclin-dependent protein kinasesMechanisms and biology of signalling by serine/threonine kinase receptors form the TGFss superfamilyThe ATM and DNA-PK proteins: The sensing, signaling and repair of DNA Damage

Editorial Reviews

" ... the book can be thoroughly recommended to anyone interested in the field." Trends in Cell Biology