Protein Lipidation

Other | October 1, 2000

byTamanoi, Fuyuhiko, Fuyuhiko Tamanoi

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This is the first compilation of protein lipidation enzymes. This volume summarizes recent dramatic developments regarding enzymes responsible for protein lipidation, a process critical for a number of physiological functions, including cell proliferation and morphology. Inhibitors of protein lipidation have recently been shown to be useful as anticancer drugs. Enzymatic mechanisms, mutational analysis, and structural studies are presented.

Key Features
* The enzymatic mechanisms of protein lipidation
* Three-dimensional structures of protein farnesytransferase, protein geranylgeranytransferase II, and n-myristoryltransferase

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From the Publisher

This is the first compilation of protein lipidation enzymes. This volume summarizes recent dramatic developments regarding enzymes responsible for protein lipidation, a process critical for a number of physiological functions, including cell proliferation and morphology. Inhibitors of protein lipidation have recently been shown to be u...

Format:OtherDimensions:322 pages, 1 × 1 × 1 inPublished:October 1, 2000Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0080542433

ISBN - 13:9780080542430

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Table of Contents

Preface.
Mechanism of Catalysis by Protein Farnesyltransferase,R.A. Spence and P.J. Casey.
Structure of Protein Farnesyltransferase,K.L. Terry, S.B. Long, and L.S. Beese.
Mutational Analyses of Protein Farnesyltransferase,J. Urano, W. Yang, and F. Tamanoi.
Farnesyltransferase Inhibitors,J.B. Gibbs.
Protein Geranylgeranyltransferase Type I,K. Yokoyama and M.H. Geleb.
Biochemistry of Rab Geranylgeranyltransferase,M.C. Seabra.
Postisoprenylation Protein Processing: CXXX (CaaX) Endoproteases and Isoprenylcysteine Carboxyl Methyltransferase,S.G. Young, P. Ambroziak, E. Kim, and S. Clarke.
Reversible Modification of Proteins with Thioester-Linked Fatty Acids,M.E. Linder.
Biology and Enzymology of Protein N-Myristoylation,R.S. Bhatnagar, K. Ashrafi, K. Futterer, G. Waksman, and J.I. Gordon.
Chapter References.
Author Index.
Subject Index.