Protein Misfolding, Aggregation and Conformational Diseases: Part B: Molecular Mechanisms of…

Hardcover | February 21, 2007

EditorVladimir N. Uversky, Anthony Fink

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The second volume continues to fill the gap in protein review and protocol literature. It does this while summarizing recent achievements in the understanding of the relationships between protein misfoldings, aggregation, and development of protein deposition disorders. The focus of Part B is the molecular basis of differential disorders.

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From the Publisher

The second volume continues to fill the gap in protein review and protocol literature. It does this while summarizing recent achievements in the understanding of the relationships between protein misfoldings, aggregation, and development of protein deposition disorders. The focus of Part B is the molecular basis of differential disorde...

From the Jacket

Protein Misfolding, Aggregation and Conformational Diseases, Part B: Molecular Mechanisms of Conformational Diseases, is a comprehensive volume providing a broad and detailed discussion of the relationships of protein misfolding and aggregation with the pathogenesis of numerous conformational diseases. While the Part A was dedicated to...

Format:HardcoverDimensions:564 pages, 9.25 × 6.1 × 0.9 inPublished:February 21, 2007Publisher:Springer USLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:038736529X

ISBN - 13:9780387365299

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Table of Contents

The Pathogenesis of Alzheimer's Disease.- Free Radicals, Metal Ions and AB Aggregation and Neurotoxicity.- The Pathogenesis of Parkinson's Disease.- A-Synuclein Aggregation and Parkinson's Disease.- Cell Biology of A-Synuclein and PD.- Pathogenesis of Prion Diseases.- Mamalian Prion Proteins.- The Yeast Prion Proteins Sup35p And Ure2p.- Immunoglobulin Light Chain and Systemic AL Amyloidosis.- Islet Amyloid and Type 2 Diabetes.- B2-Microglobulin and Dialysis-Related Amyloidosis.- Serum Amyloid A and AA Amyloidosis.- Transthyretin and Familial Amyloid Polyneuropathy.- Human Lysozyme.- Serine Proteinase Inhibitors (Serpins) in Pathophysiology.- Human Cu/Zn Superoxide Dismutase and Familial Amyotrophic Lateral Sclerosis.- Understanding the Effects of Cancer-Associated Mutations in the Tumor Suppressor Protein P53. Protein Aggregation in Muscle Fibres And Respective Neuromuscular Disorders.- Muscular Dystrophies and Protein Mutations.- The Functional Consequences of the Dystrophin Deficiency In Skeletal Muscles.- The Eye Lens Proteins and Cataracts.- Glutamine/Asparagine-Rich Regions in Proteins ad Polyglutamine Diseases.- Ataxins and Spinocerebellar Ataxias.- Molecular Pathogenesis of The Polyglutamine Disease: Spinal and Bulbar Muscular Atrophy.- Nonenzymatic Glycation (Maillard Reaction) of Crystallins and Cataracts.- Defective Glycosilation and Muscular Dystrophies.