Protein-Protein Interactions as New Drug Targets by Enno KlussmannProtein-Protein Interactions as New Drug Targets by Enno Klussmann

Protein-Protein Interactions as New Drug Targets

EditorEnno Klussmann, John Scott

Paperback | October 19, 2010

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Disease-relevant intracellular protein-protein interactions occurring at defined cellular sites possess great potential as drug targets. They permit highly specific pharmacological interference with defined cellular functions. Drugs targeting such interactions are likely to act with fewer side effects than conventional medication influencing whole cell functions. This book discusses therapeutically relevant protein-protein interactions with a major focus on scaffolding proteins tethering signal transduction processes to defined cellular compartments by direct protein-protein interactions. Recent advances in the development of pharmacological agents interfering with protein-protein interactions are highlighted.
Title:Protein-Protein Interactions as New Drug TargetsFormat:PaperbackDimensions:527 pages, 9.25 × 6.1 × 0.68 inPublished:October 19, 2010Publisher:Springer Berlin HeidelbergLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3642091946

ISBN - 13:9783642091940

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Table of Contents

Preface.- Part I. Organization of Scaffolds.- Part II. Scaffolding Proteins and Cellular Signalling.- Part III. Cell Type-Specific Anchoring.- Part IV. Interference With Protein-Protein Interaction Sites as a New Pharmacological Concept.