Protein-protein Recognition by Colin KleanthousProtein-protein Recognition by Colin Kleanthous

Protein-protein Recognition

EditorColin Kleanthous

Paperback | October 15, 2000

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The purpose of Protein-Protein Recognition is to bring together concepts and systems pertaining to protein-protein interactions in a single unifying volume. In the light of the information from the genome sequencing projects and the increase in structural information it is an opportune time totry to make generalizations about how and why proteins form complexes with each other. The emphasis of the book is on heteromeric complexes (complexes in which each of the components can exist in an unbound state) and will use well-studied model systems to explain the processes of formingcomplexes. After an introductory section on the kinetics, thermodynamics, analysis, and classification of protein-protein interactions, weak, intermediate, and high affinity complexes are dealt with in turn. Weak affinity complexes are represented by electron transfer proteins and integrincomplexes. Anti-lysozyme antibodies, the MHC proteins and their interactions with T-cell receptors, and the protein interactions of eukaryotic signal transduction are the systems used to explain complexes with intermediate affinities. Finally, tight binding complexes are represented by theinteraction of protein inhibitors with serine proteases and by nuclease inhibitor complexes. Throughout the chapters common themes are the technologies which have had the greatest impact, how specificity is determined, how complexes are stabilized, and medical and industrial applications.
Colin Kleanthous is at University of East Anglia, Norwich.
Title:Protein-protein RecognitionFormat:PaperbackPublished:October 15, 2000Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199637601

ISBN - 13:9780199637607

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Table of Contents

Kinetics and thermodynamics of protein-protein interactionsAnalysis and classification of protein-protein interactions from a structural perspectiveProtein-protein complexes formed by electron transfer proteinsMolecular basis of integrin-dependent cell adhesionStructure and energetics of anti-lysozyme antibodiesProteins of the major histocompatibility complex and their interactions with T-cell receptorsProtein-protein interactions in eukaryotic signal transductionInteraction of standard mechanism, canonical protein inhibitors with serine proteinasesNuclease inhibitors

Editorial Reviews

" The book is nicely produced with a generous list of references. The distinguished authors have produced scholarly contributions which can be throughly recommended for those concerned with this important field." Biochemistry and Molecular Biology Education