Protein Structure and Diseases

Other | May 1, 2011

byDonev, Rossen, Rossen Donev

not yet rated|write a review

Structural genomics is the systematic determination of 3D structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome.

While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large-scale cloning, expression and purification. One main advantage of this approach is economy of scale.



  • Examines the three dimensional structure of all proteins of a given organism, by experimental methods such as X-ray crystallography and NMR spectroscopy
  • Looks at structural genomics as a foundation of drug discovery as discovering new medicines is becoming more challenging and the pharmaceutical industry is looking to new technologies to help in this mission

Pricing and Purchase Info

$167.79 online
$217.85 list price (save 22%)
In stock online
Ships free on orders over $25

From the Publisher

Structural genomics is the systematic determination of 3D structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This i...

Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2010 Dr. Donev was ap...

other books by Donev, Rossen

Protein-Nucleic Acids Interactions
Protein-Nucleic Acids Interactions

Kobo ebook|Jun 19 2013

$189.00

Ion Channels as Therapeutic Targets, Part B
Ion Channels as Therapeutic Targets, Part B

Kobo ebook|Mar 31 2016

$189.00

Proteomics in Biomedicine and Pharmacology
Proteomics in Biomedicine and Pharmacology

Kobo ebook|Jul 3 2014

$189.00

see all books by Donev, Rossen
Format:OtherDimensions:312 pages, 1 × 1 × 1 inPublished:May 1, 2011Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0123812631

ISBN - 13:9780123812636

Customer Reviews of Protein Structure and Diseases

Reviews

Extra Content

Table of Contents

  1. Graphical representation and mathematical characterization of protein sequences and applications to viral proteins Ambarnil Ghosh and Ashesh Nandy
  2. Structural, thermodynamic and mechanistical studies in uroporphyrinogen III synthase. Molecular basis of congenital erythropoietic porphyria Arola Fortian, David Castaño, Esperanza Gonzalez, Ana Laín, Juan M. Falcon-Perez and Oscar Millet
  3. Role of Fibrin Structure in Thrombosis and Vascular Disease Amy L. Cilia La Corte, Helen Philippou and Robert A. S. Ariëns
  4. Structural, Dynamic, and Functional Aspects of Helix Association in Membranes: a Computational View Anton A. Polyansky, Pavel E. Volynsky, Roman G. Efremov
  5. Proteins MOVE! Protein dynamics and long-range allostery in cell signaling Zimei Bu and David J. E. Callaway
  6. Structural diversity of class I MHC like molecules and its implications in binding specificities Md. Imtaiyaz Hassan and Faizan Ahmad