Proteins: Membrane Binding and Pore Formation by Gregor AnderluhProteins: Membrane Binding and Pore Formation by Gregor Anderluh

Proteins: Membrane Binding and Pore Formation

EditorGregor Anderluh, Jeremy H. Lakey

Hardcover | May 21, 2010

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There are currently only two structures of pores available, of ?-toxin from Staphylococcus aureus and hemolysin E from Escherichia coli. So what we know about these proteins was obtained over many years of intense experimentation. We have nevertheless, in the last couple of years, witnessed a significant rise in structural information on the soluble forms of pore-forming proteins. Surprisingly, many unexpected similarities with other proteins were noted, despite extremely low or insignificant sequence similarity. It appears that lipid membrane binding and formation of transmembrane channels is achieved in many cases by a limited repertoire of structures. This book describes how several of the important pore forming toxin families achieve membrane binding and which structural elements are used for formation of transmembrane pores. Our contributors have thus provided the means for a comparative analysis of several unrelated families.
Gregor Anderluh is Associate Professor of Biochemistry at the Department of Biology, Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia. He and his coworkers are studying protein-membrane interactions and how cellular membranes are damaged by proteins. He is a director of the Infrastuctural Centre for Surface Plasmon Re...
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Title:Proteins: Membrane Binding and Pore FormationFormat:HardcoverDimensions:168 pagesPublished:May 21, 2010Publisher:Springer New YorkLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:144196326X

ISBN - 13:9781441963260

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Table of Contents

1. IntroductionSusanne C. Feil, Galina Polekhina, Michael A. Gorman and Michael W. ParkerAbstractIntroductionNomenclatureThree-Dimensional Structures of Pore-Forming ProteinsMembrane BindingOligomerizationCommon Features of Membrane InsertionConclusion2. Energetics of Peptide and Protein Binding to Lipid MembranesWilliam C. WimleyAbstractThe Lipid Bilayer PhaseHydrophobic InteractionsElectrostatic InteractionsAdditivity between Electrostatic and Hydrophobic InteractionsThe Influence of Peptide and Protein StructureSpecific InteractionsSpecificity: The Formation of Ordered PoresPromiscuity: Membrane-Permeabilization by Interfacial ActivityConclusion3. Membrane Association and Pore Formation by Alpha-Helical PeptidesBurkhard BechingerAbstractIntroductionAlamethicin and Other PeptaibolsCationic Amphipathic Antimicrobial PeptidesMembrane ProteinsConclusion4. Role of Membrane Lipids for the Activity of Pore Forming Peptides and ProteinsGustavo Fuertes, Diana Giménez, Santi Esteban-Martín, Ana J. García-Sáez, Orlando Sánchez and Jesús SalgadoAbstractIntroductionMembrane Interfaces Are Ideal Binding Sites for Pore-Forming Peptidesand ProteinsA Membrane Foldase Activity Configures Peptide and Protein Active StructuresRole of Lipids in the Formation and Stabilization of PoresPhysical Properties of Polypeptide-Induced Pores Related to the Role of LipidsConclusion5. Cholesterol-Dependent CytolysinsRobert J.C. GilbertAbstractFunctional Studies on CDCsMembrane binding by CDCsPore Formation by CDCsProteolipid PoresOligomerisation- A Mechanism for Membrane InsertionComplex Effects of CDCs and Related ProtiensConclusion6. Laetiporus sulphureus Lectin and Aerolysin Protein FamilyJosé Miguel Mancheño, Hiroaki Tateno, Daniel Sher and Irwin J. GoldsteinAbstractIntroductionPore-Forming Hemolytic LectinsA New Member within the Aerolysin Family: The Crystal Structure of LSLaOligomeric State of Water-Soluble LSLaA Common Aerolysin-Like Pore-Forming Module Structure?Other New Members in the Aerolysin Family: Basic Aerolysin Pore-FormingMotifs?Conclusion7. Interfa cial Interactions of Pore-Forming ColicinsHelen Ridley, Christopher L. Johnson and Jeremy H. LakeyAbstractIntroductionStructuresReceptor BindingTranslocationCrossing the PeriplasmInner Membrane Inserted FormsConclusion8. Permeabilization of the Outer Mitochondrial Membrane by Bcl-2 ProteinsAna J. García-Sáez, Gustavo Fuertes, Jacob Suckale and Jesús SalgadoAbstract IntroductionThe Structure of the Bcl-2 ProteinsPore-Forming Properties of Bcl-2 ProteinsRegulation of MOM Permeabilization by Bcl-2 ProteinsConclusion9. Molecular Mechanism of Sphingomyelin-Specific Membrane Binding and Pore Formation by ActinoporinsBiserka Bakrac and Gregor AnderluhAbstract IntroductionStructural Properties of ActinoporinsActinoporins Specifically Bind Sphingomyelin as the First Step in PoreFormationFlexibility of the N-Terminal Region is Required for Pore FormationPore Formation Involves Nonlamellar Lipid StructuresSimilarity to Other ProteinsConclusion10. Hemolysin E (HlyE, ClyA, SheA) and Related ToxinsStuart Hunt, Jeffrey Green and Peter J. ArtymiukAbstract IntroductionRegulation of hlyE ExpressionStructural Studies on HlyEProcess of Membrane InsertionHlyE Secretion and Exploitation in Vaccine Development and TumourTargetingHlyE-Like Toxins from Bacillus cereusConclusion11. Pore formation by Cry toxinsMario Soberón, Liliana Pardo, Carlos Muñóz-Garay, Jorge Sánchez, Isabel Gómez, Helena Porta and Alejandra BravoAbstractIntroductionMechanism of Action of Cry ToxinsSolubilization and Proteolytic Activation of Cry toxinsBinding Interaction with ReceptorsRole of Cry toxin-Receptor Interaction in ToxicityOligomerization of Cry toxinsPore formationSynergism between Cry and Cyt toxinsConclusion12. Role of Hepa ran Sulfa tes and Glycosphingolipids in the Pore Formation of Basic Polypeptides of Cobra CardiotoxinWen-guey Wu, Siu-Cin Tjong, Po-long Wu, Je-hung Kuo and Karen WuAbstractIntroductionAmphiphilic Properties of Three-Fingered CTXsDiverse Targets of CTX HomologuesCTX A3 Pores in Sulfatide Containing MembranesPore Formations also Trigger EndocytosisHS Facilitate Cell Surface Retention of CTXsHS Stabilizes Membrane Bound Form of CTXFrom HS to Membrane SulfatidesPeripheral Binding ModesLipid Headgroup Conformational Change to Facilitate CTX InsertionPore DynamicsConclusion13. Amyloid Peptide Pores and The Beta SheetConformationBruce L. Kagan and Jyothi ThundimadathilAbstractIntroductionAggregation and Fibril Formation: Hallmark of Amyloid PeptidesInteraction of Amyloid Peptides and Membranes during Ion ChannelFormationSimilarities between Pore-Forming Toxins and Amyloid PoresB-Sheet Peptide PoresMechanism of Ion Channel Formation by Beta Sheet PeptidesConclusionIndex