Proteomic and Metabolomic Approaches to Biomarker Discovery

Other | May 20, 2013

byHaleem J Issaq, Haleem J Issaq, Timothy D. Veenstra

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Proteomic and Metabolomic Approaches to Biomarker Discoverydemonstrates how to leverage biomarkers to improve accuracy and reduce errors in research. Disease biomarker discovery is one of the most vibrant and important areas of research today, as the identification of reliable biomarkers has an enormous impact on disease diagnosis, selection of treatment regimens, and therapeutic monitoring. Various techniques are used in the biomarker discovery process, including techniques used in proteomics, the study of the proteins that make up an organism, and metabolomics, the study of chemical fingerprints created from cellular processes.

Proteomic and Metabolomic Approaches to Biomarker Discoveryis the only publication that covers techniques from both proteomics and metabolomics and includes all steps involved in biomarker discovery, from study design to study execution. The book describes methods, and presents a standard operating procedure for sample selection, preparation, and storage, as well as data analysis and modeling. This new standard effectively eliminates the differing methodologies used in studies and creates a unified approach. Readers will learn the advantages and disadvantages of the various techniques discussed, as well as potential difficulties inherent to all steps in the biomarker discovery process.

A vital resource for biochemists, biologists, analytical chemists, bioanalytical chemists, clinical and medical technicians, researchers in pharmaceuticals, and graduate students,Proteomic and Metabolomic Approaches to Biomarker Discoveryprovides the information needed to reduce clinical error in the execution of research.



  • Describes the use of biomarkers to reduce clinical errors in research
  • Includes techniques from a range of biomarker discoveries
  • Covers all steps involved in biomarker discovery, from study design to study execution

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From the Publisher

Proteomic and Metabolomic Approaches to Biomarker Discoverydemonstrates how to leverage biomarkers to improve accuracy and reduce errors in research. Disease biomarker discovery is one of the most vibrant and important areas of research today, as the identification of reliable biomarkers has an enormous impact on disease diagnosis, sel...

Format:OtherDimensions:488 pages, 1 × 1 × 1 inPublished:May 20, 2013Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0123947952

ISBN - 13:9780123947956

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Table of Contents

  1. Biomarker Discovery: Study Design and Execution
  2. Proteomic Technologies for Biomarker Discovery
  3. Sample Preparation for Proteomics
  4. Sample preparation For metabolomics
  5. SOP for serum and plasma
  6. Current NMR Strategies
  7. Data-independent Mass Spectrometry Extends Detectable Dynamic Range
  8. GC/MS
  9. LC/MS for: (a) Metabolomics
  10. CE/MS for (a) Proteomics (b) Metabolomics
  11. Gel electrophoresis
  12. The Role of Two-dimensional Gel Electrophoresis in Biomarker Discovery
  13. Affinity
  14. Asp selective Microwave-supported acid proteolysis
  15. Fractionation of complex mixtures
  16. Protein and Metabolite Identification
  17. Quantitative proteomics
  18. Quantitative analysis of metabolites in biological fluids
  19. Statistical & computational analysis
  20. Top-down Proteomics for Biomarker Discovery
  21. A role for protein-protein interaction networks in the identification and characterization of potential biomarkers
  22. Protein microarrays
  23. Autoantibodies as biomarkers
  24. MicroRNAs and Biomarker Discovery
  25. Tissue imaging for biomarker discovery
  26. MS approaches for biomarker verification
  27. MS metabolomic data handling for biomarker discovery
  28. Biomarker Validation