Proteomics of Spermatogenesis

Hardcover | May 26, 2005

byG. S. Gupta

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Recent developments of experimental techniques in cellular and molecular biology have made it possible to understand the molecular biology of male gametogenesis in greater detail. This book focuses on the description of specialized proteins, which are dominantly and/or specifically expressed in germ cells and localized in spermatozoa. There is an urgent need to classify proteins of spermatogenic cells with a view of their functions, and their applications in the regulation of fertility and in understanding infertility. The understanding of structural properties of male germ cell specific proteins can offer vulnerable points for targeted intervention in testis without generalized effects on stages of spermatogenesis. Besides targeted action in male germ cells, sperm specific proteins and polypeptides may also offer potential application in the development of a contraceptive vaccine.

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Recent developments of experimental techniques in cellular and molecular biology have made it possible to understand the molecular biology of male gametogenesis in greater detail. This book focuses on the description of specialized proteins, which are dominantly and/or specifically expressed in germ cells and localized in spermatozoa. ...

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Recent developments of experimental techniques in cellular and molecular biology have made it possible to understand the molecular biology of male gametogenesis in greater detail. This book focuses on the description of specialized proteins, which are dominantly and/or specifically expressed in germ cells and localized in spermatozoa. ...

Dr. Gupta is a former Professor and Chairman of the Department of Biophysics, Panjab University, Chandigarh, India. His primary areas of research are molecular and cellular biology, reproductive biology/reproductive immunology, enzymology/enzyme technology, and radiation biology. As a visiting researcher, he has worked at many instit...

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Format:HardcoverDimensions:881 pages, 9.61 × 6.69 × 0.27 inPublished:May 26, 2005Publisher:Springer USLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:038725398X

ISBN - 13:9780387253985

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Table of Contents

1. Spermatogenesis.2. Paracrine Role of Sertoli Cell. 3. Non-Steroidal Signal Molecules in Spermatogenesis. 4. Specificity of Retinol, Estrogen and Steroid Linked Proteins. 5. Homeostasis of Germ Cells and Apoptosis. 6. Nuclear Skeleton Proteins: Non-Histones. 7. Nuclear Skeleton Proteins: Chromosomal Basic Proteins. 8. Microtubules. 9. Microtubule Based Motor Proteins. 10. Sex Chromosomal Proteins and Autosomal Homologues. 11. Cell Cycle Components. 12. Isoproteins in DNA Synthesis. 13. DNA Repair and Recombination. 14. Transcriptional Control. 15. Proteins in Transcriptional Activity of Spermatogenic Cells. 16. Transcription Factors Associated with Spermatogenesis. 17. Proto-Oncoproteins. 18. G Proteins and Associated Signal Transduction Molecules. 19. Protein Kinases. I. Serine/Threonine Kinases. II. Protein Tyrosine Kinases. III. Dual Specificity Protein Kinases. 20. Protein Phosphatases. I. Serine/Threonine Kinases. II. Protein Tyrosine Phosphatases. III. Dual Specificity Protein Phosphatases.21. Ion Channels and Aquaporins. 22. Action of Phospholipases. 23. Acrosomal Enzymes. 24. Acrosomal Proteins (Non-Enzymatic). 25. Actions and Myosins. 26. Cell Adhesion Proteins. 27. Metalloproteases and Metalloprotease Inhibitors. 28. Isoenzymes in Energy Pathways. 29. Fibrous Sheath, Dense Fibers, and Plasma Membrane of Sperm. 30. Proteins in Antiperoxidation. 31. Quality Control of Germ Cell Proteins. I. Ubiquitination and Proteolysis. II. Molecular Chaperons.32. Cancer Associated Testis Antigens. 33. Selective Group of Germ Cell Specific Proteins. 34. Sperm Maturation in Epididymis. Index.