Psychiatric Disorders: Methods and Protocols by Firas H. KobeissyPsychiatric Disorders: Methods and Protocols by Firas H. Kobeissy

Psychiatric Disorders: Methods and Protocols

byFiras H. Kobeissy

Hardcover | January 10, 2012

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New high throughput techniques in neuroscience and psychiatry have enhanced the development of experimental, customizable animal models that are predictive of human neuropsychiatric pathology and give vital insights on the mechanisms and pathways involved. In Psychiatric Disorders: Methods and Protocols, key experts have written integrated chapters on neuropsychiatric research sharing their insightful expertise and opinions focusing on both the animal models as well as the cutting edge techniques applied. Beginning with an overview of the animal research in psychiatric illness and substance abuse, this comprehensive volume continues with the modeling of neuropsychiatric illness, drug abuse paradigms and techniques, biomarker identification, autoimmune inflammatory response, and neuroendocrine alteration in the areas of psychiatry, as well as state-of-the-art "Omics approaches" and neurosystems biology/data mining techniques to compute and analyze genomic and proteomics alteration occurring within neuropsychiatric models.  As a part of the highly successful Methods in Molecular BiologyT series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.


Thorough and easily applicable, Psychiatric Disorders: Methods and Protocols offers the detailed and clearly illustrated tools necessary for neuroscientists and psychiatrists to handle many unanswered scientific questions with a more creative and insightful approach.
Title:Psychiatric Disorders: Methods and ProtocolsFormat:HardcoverDimensions:615 pagesPublished:January 10, 2012Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617794570

ISBN - 13:9781617794575

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Table of Contents

Part I: Overview of the Animal Research in Psychiatric Illness and Substance Abuse


1. New Frontiers in Animal Research of Psychiatric Illness

            Arie Kaffman and John J. Krystal


2. Experimental Psychiatric Illness and Drug Abuse Models: From Human to Animal, An Overview

            Scott Edwards and George F. Koob


3. Qualitative Vs. Quantitative Methods in Psychiatric Research

            Mahdi Razafsha, Hura Behforuzi, Hassan Azari, Zhiqun Zhang,Kevin K. Wang, Firas H. Kobeissy, and Mark S. Gold


Part II: Methods in Animal Models of Psychiatric Illness


4. Animal Models of Self-Injurious Behavior: An Overview

            Darragh P. Devine


5. Rodent Models of Adaptive Decision Making

            Alicia Izquierdo  and Annabelle M. Belcher


6. Animal Models of Depression and Neuroplasticity: Assessing Drug Action in Relation to Behavior and Neurogenesis

            Ying Xu, Philip A. Barish, Jianchun Pan, William O. Ogle, and James M. O'Donnell


7. Modeling Depression in Animal Models

            David H. Overstreet


8. Behavioral Model for Assessing Cognitive Decline

            Michael Guidi and Thomas C. Foster


9. The Pemoline Model of Self-Injurious Behavior

            Darragh P. Devine


10. Modeling Risky Decision Making in Rodents

            Nicholas W. Simon and Barry Setlow


11. Modeling Open Space Anxiety Test in Rodents: The Elevated Platform with Steep Slopes

            Abdelkader Ennaceur


12. An Animal Model to Study the Molecular Basis of Tardive Dyskinesia

            Mahendra Bishnoi and Ravneet K. Boparai


Part III: Methods in Animal Models of Substance Abuse


13. Models of Chronic Alcohol Exposure and Dependence

            Darin J. Knapp and George R. Breese


14. Rat Models of Prenatal and Adolescent Cannabis Exposure

            Jennifer A. DiNieri and Yasmin L. Hurd


15. Modeling Nicotine Addiction in Rats

            Stephanie Caille, Kelly Clemens, Luis Stinus, and Martine Cador


16. Animal Models of Nicotine Withdrawal: Intracranial Self-Stimulation and Somatic Signs of Withdrawal

            Rayna M. Bauzo and Adrie W. Bruijnzeel


17. Methods in Drug Abuse Models: Comparison of Different Models of Methamphetamine Paradigms

            Firas H. Kobeissy, Jeremiah D. Mitzelfelt, Irina Fishman, Drake Morgan, Roger Gaskins, Zhiqun Zhang, Mark S Gold, and Kevin Wang


18. Cocaine Self-Administration in Rats: Hold Down Procedures

            Benjamin A. Zimmer and David C.S. Roberts


19. Cocaine Self-Administration in Rats: Discrete Trials Procedures

            Carson V. Dobrin and David C.S. Roberts


20. Cocaine Self-Administration in Rats: Threshold Procedures

            Erik B. Oleson and David C.S. Roberts


21. Assessing Locomotor-Stimulating Effects of Cocaine in Rodents

            Drake Morgan, Jameson P. DuPree, Alex D. Bibbey, and Glen M. Sizemore


22. Methods in Tobacco Abuse: Proteomic Changes Following Second-Hand Smoke Exposure

            Joy Guingab-Cagmat, Rayna M. Bauzo, Adrie W. Bruijnzeel, Kevin Wang, Mark S. Gold, and Firas H. Kobeissy


Part IV: Methods in Animal Models of Eating Disorders


23. Animal Models of Sugar and Fat Bingeing: Relationship to Food Addiction and Increased Body Weight

            Nicole M. Avena, Miriam E. Bocarsly, and Bartley G. Hoebel


24. Animal Models of Overeating

            Neil E. Rowland


25. The Activity-Based Anorexia Mouse Model

            Stephanie J. Klenotich and Stephanie C. Dulawa


Part V: Biomarkers, Neuroendocrine and Inflammatory Profiles Relevant to Neuropsychiatric Disorders


26. Dissociating Behavioral, Autonomic, and Neuroendocrine Effects of Androgen Steroids in Animal Models

            Amy S. Kohtz and Cheryl A. Frye


27. Interleukin-2 and the Septohippocampal System: Intrinsic Actions and Autoimmune Processes Relevant to Neuropsychiatric Disorders

            John M. Petitto, Zhi Huang, Danielle Meola, Grace K. Ha, and Daniel Dauer


28. Experimental Schizophrenia Models in Rodents Established with Inflammatory Agents and Cytokines

            Hiroyuki Nawa and Kiyofumi Yamada


29. P11: A Potential Biomarker for Posttraumatic Stress Disorder (PTSD)

            Lei Zhang and He Li


Part VI: "Omics" Analysis and Systems Biology Applications in Psychiatric Disorders


30. Investigation of Age-Specific Behavioral and Proteomic Changes in an Animal Model of Chronic Ethanol Exposure

            Antoniette M. Maldonado-Devincci, Stanley M. Stevens, Jr., and Cheryl L. Kirstein


31. Quantitative Peptidomics to Measure Neuropeptide Levels in Animal Models Relevant to Psychiatric Disorders

            Julia S. Gelman, Jonathan Wardman, Vadiraja B. Bhat, Fabio C. Gozzo, and Lloyd D. Fricker


32. ADHD Animal Model Characterization: Transcriptomics and Proteomics Analyses

            Yoshinori Masuo, Junko Shibato, and Randeep Rakwal


33. Psychiatric Disorder Biomarker Discovery Using Quantitative Proteomics

            Michaela D. Filiou and Christoph W. Turck


34. Gene Profiling of Laser-Microdissected Brain Regions and Individual Cells in Drug Abuse and Schizophrenia Research

            Pietro Paolo Sanna, Vez Repunte-Canonigo, and Alessandro Guidotti


35. Stable Isotope Labeling with Amino Acids in Cell Culture (SILAC)-Based Proteomic Analysis of Ethanol-Induced Protein Expression Profiles in Microglia

            Bin Liu, David S. Barber, and Stanley M. Stevens, Jr.


36. Systems Biology in Psychiatric Research: From Complex Data Sets Over Wiring Diagrams to Computer Simulations

            Felix Tretter and Peter J. Gebicke-Haerter


37. Data Mining in Psychiatric Research

            Diego Tovar, Eduardo Cornejo, Petros Xanthopoulos, Mario R. Guarracino, and Panos M. Pardalos

Editorial Reviews

From the reviews:"This is a comprehensive compilation of in vivo and in vitro neuropsychiatric research methods and protocols on animal models and cutting-edge techniques in the wide spectrum of psychiatric illnesses. . It is written for graduates, postdoctoral workers, and established scientists working on behavioral and molecular neuropsychiatric research. . The detailed methods and protocols make this a quality book for any researcher in the field of neuroscience and psychiatry." (Valerie E. Mathis-Allen, Doody's Book Reviews, May, 2012)