Psychiatric Epidemiology: Searching for the Causes of Mental Disorders

Hardcover | June 1, 2006

byEzra Susser, Sharon Schwartz, Alfredo Morabia

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Searching for the causes of mental disorders is as exciting as it it complex. The relationship between pathophysiology and its overt manifestations is exceedingly intricate, and often the causes of a disorder are elusive at best. This book is an invaluable resource for anyone trying to trackthese causes, whether they be clinical researchers, public health practitioners, or psychiatric epidemiologists-in-training. Uniting theory and practice in very clear language, it makes a wonderful contribution to both epidemiologic and psychiatric research. Rather than attempting to review thedescriptive epidemiology of mental disorders, this book gives much more dynamic exposition of the thinking and techniques used to establish it.Starting out by tracing the brief history of psychiatric epidemiology, the book describes the study of risk factors as causes of mental disorders. Subsequent sections discuss approaches to investigation of biologic, genetic, or social causes and the statistical analysis of study results. The bookconcludes by following some of the problems involved in the search for genetic causes of mental disorders, and more complex casual relationships.

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From the Publisher

Searching for the causes of mental disorders is as exciting as it it complex. The relationship between pathophysiology and its overt manifestations is exceedingly intricate, and often the causes of a disorder are elusive at best. This book is an invaluable resource for anyone trying to trackthese causes, whether they be clinical rese...

Ezra Susser is at Columbia University. Sharon Schwartz is at Columbia University.

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Format:HardcoverDimensions:544 pages, 7.01 × 10 × 1.5 inPublished:June 1, 2006Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0195101812

ISBN - 13:9780195101812

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Table of Contents

PART I. Psychiatric epidemiology, then and now. 1. The burden of mental illness2. The arc of epidemiology3. Searching for the causes of mental disordersPART II. RISK FACTORS AS CAUSES OF MENTAL DISORDERS. 4. What is a cause?5. Detecting causes6. Study designs7. Relationship among causes8. Measures of associationPART III. COHORT DESIGNS IN PSYCHIATRIC EPIDEMIOLOGY. 9. Prototypical cohort study10. Diversity of cohort studies11. Casual inference: a thought experiment12. Confounding: What it is and what can be done13. Unequal attrition under different types of follow-up14. Differential misclassificationPART IV. CASE CONTROL DESIGNS IN PSYCHIATRIC EPIDEMIOLOGY. 15. Logic of the case control design16. Applications of the case control study17. Choosing controls18. Comparability and the case control studyPART V. CASE CONTROL DESIGNS IN BIOLOGIC PSYCHIATRY. 19. Biologic studies in psychiatry20. Choosing cases in biologic psychiatry21. Choosing controls in biologic psychiatryPART VI. ANALYZING THE DATA. 22. Gauging associations23. Establishing associations24. Planning studies: power and sample size25. Statistical adjustment26. Survival analysis27. Analysis of InteractionPART VII. THE SEARCH FOR GENETIC CAUSES OF MENTAL DISORDERS. 28. Integrating epidemiology with genetics29. Genetic association studies30. Modern family history studies31. Twin studies of heritability32. Genetic linkage studies33. Designs for the genomic eraPART VIII. COMPLEX CASUAL RELATIONSHIPS. 34. Eco-epidemiology35. Casual explanation within a risk factor framework36. Casual explanation outside the black box37. Dependent and dynamic processesAppendix I. Our approach to epidemiologic concepts and methods. Appendix II.(Appendix to Chapter 13) Application of survival analysis to PDSE data. Glossary.

Editorial Reviews

"If only all textbooks were written like this one. The authors of Psychiatric Epidemiology have assembled a highly cogent examination of the past, present, and possible future of psychiatric epidemiology, doing so in a way that anyone interested in the scientific method--including itslimitations--can be immersed."--Psychiatric Times