Psychiatric Pharmacogenomics by David A. Mrazek

Psychiatric Pharmacogenomics

byDavid A. Mrazek

Hardcover | June 11, 2010

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Psychiatric Pharmacogenomics is a book written to help clinicians to use pharmacogenomic testing to improve the pharmacotherapy that they provide for their patients. It is designed to teach clinicians how to order pharmacogenomic tests and interpret the results. Clinical examples are used tounderscore the specific indications for pharmacogenomic testing and to clarify the clinical usefulness of identifying atypical genotypes that result in problematic responses to medication.The first section of the book begins with a basic review of molecular genetics. Additionally, the book also includes an extensive glossary of technical terms associated with molecular genetics and pharmacogenomics. The clinical utility of pharmacogenomic testing is demonstrated throughout the bookby describing the implications of genetic variations for the care of individual patients. The second section of the book is organized into fourteen chapters that each focus on the clinical implications of testing for specific genes for which variants have been associated with either therapeutic response or side effects of psychotropic medications. Each of these chapters is structured inthe same manner and involves a description of the gene and its significant variants. Each chapter also includes one or more clinical vignettes. The third section of the book discusses the clinical usefulness of pharmacogenomic testing, ethical issues associated with pharmacogenomic testing, and provides predictions for the future development of more sophisticated pharmacogenomic testing.

About The Author

David A. Mrazek is Chair of Psychiatry and Psychology and Director of the SC Johnson Genomics of Addictions Program at the Mayo Clinic School of Medicine in Rochester, Minnesota.
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Title:Psychiatric PharmacogenomicsFormat:HardcoverDimensions:280 pages, 6.3 × 9.29 × 1.1 inPublished:June 11, 2010Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0195367294

ISBN - 13:9780195367294

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Table of Contents

I. Basic FoundationsIntroduction1. The Language of Molecular Genetics2. The Fourteen Genes3. The Problem and the SolutionII. The Drug Metabolizing Enzyme Genes4. The Cytochrome P450 2D6 Gene5. The Cytochrome P450 2C19 Gene6. The Cytochrome P450 2C9 Gene7. The Cytochrome P450 1A2 GeneIII. A Gene Associated with the Metabolism of Neurotransmitters8. The Catechol-O-Methyltransferase GeneIV. The Neurotransmitter Transporter Genes9. The SLC6A2 Norepinephrine Transporter Gene10. The SLC6A3 Dopamine Transporter Gene11. The SLC6A4 Serotonin Transporter GeneV. The Serotonin Receptor Genes12. The Serotonin 1A Receptor Gene13. The Serotonin 2A Receptor Gene14. The Serotonin 2C Receptor GeneVI. The Dopamine Receptor Genes15. The Dopamine D2 Receptor Gene16. The Dopamine D3 Receptor Gene17. The Dopamine D4 Receptor GeneVII. Clinical Considerations18. The Clinical Utility of Psychiatric Pharmacogenomic Testing19. Ethical Issues to Consider When Using Pharmacogenomic Testing in Psychiatric Practice20. Future Development of Psychiatric Pharmacogenomic TestingGlossary of Genetic and Pharmacogenomic TermsGeneric and Brand Names of Pharmacogenomically Relevant DrugsIndex