Pulmonary Hypertension

Paperback | December 13, 2012

byClive Handler, Gerry Coghlan

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High pressure in the lungs, or pulmonary hypertension, is most commonly due to smoking-related lung disease and conditions affecting the left heart, for example, high blood pressure in the arteries, faulty heart valves, and a weakened heart muscle. Pulmonary arterial hypertension (PAH), is arare and complex disease, associated with many different medical conditions, which is caused by a growth of cells lining the inside of the lung arteries, resulting in high pressure in areas of the body. Both conditions lead to strain and potential failure of the right heart, and therefore awarenessand early diagnosis of the condition is needed to lead to better outcomes: however this depends on education of all specialists and primary care clinicians about PAH. This practical handbook covers both PH and PAH, providing information required by the wide range of clinicians who will encounter these conditions, including cardiologists, respiratory physicians, rheumatologists, specialists in liver and AIDS medicine, and haematologists. It covers what it is, whoit is likely to affect, how it is diagnosed, including the pitfalls of the various diagnostic tests, the different and evolving forms of treatment, long term management of this often devastating chronic disease, and the crucial role of multidisciplinary management in optimizing clinical care ofthese patients who usually have multi-system diseases. It also covers the up new classification for both PH and PAH, and new drugs that have recently become available.

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High pressure in the lungs, or pulmonary hypertension, is most commonly due to smoking-related lung disease and conditions affecting the left heart, for example, high blood pressure in the arteries, faulty heart valves, and a weakened heart muscle. Pulmonary arterial hypertension (PAH), is arare and complex disease, associated with man...

Clive Handler, BSc, MD, MRCP, FACC FESC, qualified from Guy's Hospital Medical School. He trained in cardiology at Guy's Hospital and at University College and Middlesex Hospitals. He was consultant Cardiologist at Northwick Park and St Mary's Hospitals and is now consultant in pulmonary hypertension in the National Pulmonary Hypertens...

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Format:PaperbackDimensions:288 pages, 7.09 × 3.94 × 0.01 inPublished:December 13, 2012Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199572569

ISBN - 13:9780199572564

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Table of Contents

1. History of pulmonary hypertension and the circulation2. Definitions of pulmonary hypertension and pulmonary arterial hypertension3. Clinical classification of pulmonary hyptertension4. Pathology of pulmonary hyptertension5. Pathology of chronic thromboembolic pulmonary hypertension6. Pathobiology of pulmonary arterial hypertension7. Inflammation, growth factors and thrombosis in pulmonary arterial hypertension8. Genetics and genomics of pulmonary arterial hypertension9. Epidemiology of pulmonary arterial hypertension and pulmonary hypertension10. Risk factors for pulmonary arterial hypertension11. Pathophysiology of pulmonary hypertension in non-pulmonary arterial hypertension groups12. Pulmonary arterial hypertension associated with connective tissue diseases13. Systemic sclerosis14. Systemic lupus erythematosus15. Sjogren's syndrome16. Polymyositis and dermatomyositis17. HIV18. Porto-pulmonary hypertension19. Venous thromboembolism and acute pulmonary embolism20. Acute pulmonary embolism21. Chronic thromboembolic pulmonary hypertension22. Pulmonary hypertension associated with congenital systemic-to-pulmonary cardiac shunts23. Schistomiasis24. Chronic haemolyticanaemias and pulmonary arterial hypertension25. Interstitial lung disease and pulmonary hypertension26. Prognosis of pulmonary arterial hypertension27. The right ventricle28. Clinical features of pulmonary arterial hypertension29. Haemodynamics and treatment approaches in pulmonary hypertension due to left heart disease30. Diagnostic algorithm31. Simple investigations32. Ventilation/perfusion scanning33. Echocardiography34. Non-invasive exercise testing35. Cardiac catheterisation36. Management of pulmonary arterial hypertension37. General measures38. Contraception in pulmonary arterial hypertension39. Risks of pregnancy and contraception40. Lifestyle issues41. Elective surgery in patients with pulmonary arterial hypertension42. Supportive therapy43. Management of arrhythmias44. Advanced therapies for pulmonary arterial hypertension45. Endothelin and endothelin receptor antagonists46. Phosphodiesterase-5 inhibitors47. Classes of recommendations for procedures and treatments48. Drug interactions with pulmonary arterial hypertension targeted therapies49. Combination therapy in pulmonary arterial hypertension50. Problems in conducting pulmonary arterial hypertension drug trials51. Atrial septostomy52. Translation