Quantitative Methods in Neuroscience: A Neuroanatomical Approach

Hardcover | July 21, 2004

EditorStephen M Evans, Ann Marie Janson, Jens Randel Nyengaard

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Stereology is a valuable tool for neuroscientists, allowing them to obtain 3-Dimensional information from 2-Dimensional measurements made on appropriately sampled sections (usually obtained from histological sections or MRI/CT/PET scans). This 3-D information is invaluable in correlatingstructural/functional relationships in the pursuit of far greater understanding of the function of the central nervous system. However, in carrying out such measurements, often based on limited data sets, there is a risk of experimenter bias. An important feature of modern design based stereology isto be aware of potential sources of bias and eliminate them during the data collection. With many of the major neuroscience journals now insisting that quantitative data be presented, there is a greater need than ever for neuroscientists to understand the theory and practice behind quantitativemethods, such as those offered by stereology. Quantitative Methods in Neuroscience is a cookbook of stereological methods written especially for neuroscientists. It provides clear and accessible advice about when and when not to use stereology. Throughout the book, the emphasis is on practical guidance, rather than discussions and formulae.Written by leading scientists in the field of stereology, with a Foreword by D.C. Sterio, the book will be a valuable introduction to these methods for neuroscientists, and all those involved in development of new drug programmes.

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Stereology is a valuable tool for neuroscientists, allowing them to obtain 3-Dimensional information from 2-Dimensional measurements made on appropriately sampled sections (usually obtained from histological sections or MRI/CT/PET scans). This 3-D information is invaluable in correlatingstructural/functional relationships in the pursui...

Stephen M Evans is at Hammersmith Imanet, Hammersmith Hospital, London, UK. Ann Marie Janson is in the Department of Neuroscience, Karolinska Institute, Stockholm, Sweden. Jens Randel Nyengaard is at Aarhus University Hospital, Denmark.

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Format:HardcoverDimensions:350 pages, 9.21 × 6.14 × 0.93 inPublished:July 21, 2004Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0198505280

ISBN - 13:9780198505280

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Table of Contents

1. Stephen M. Evans and Jens Randel Nyengaard: Introduction2. Luis Cruz-Orive, A.M. Insausti, R. Insausti and D. Crespo: A case study from neuroscience involving stereology and multivariate analysisSection 1: Number3. Stephen M. Evans and Jens Randel Nyengaard: Introduction4. Daniel A. Peterson: The use of fluorescent probes in cell counting procedures5. Bente Finsen, R. Gregersen, E. Lehrmann, S. Lovmand and M.J. West: Counting in situ hybridized neurons6. Jens Randel Nyengaard, K-A. Dorph-Petersen, Y. Tang: Number in electron microscopy: estimation of total number of synapses in the main regions of human neocortex7. Annemette Lokkegaard: The number of microvessels estimated by an unbiased stereological method applied in a brain regionSection 2: Volume8. Stephen M. Evans and Jens Randel Nyengaard: Introduction9. Trine Tandrup: The nucleator and the planar and optical rotators applied in rat dorsal root ganglia10. Karl-Anton Dorph-Petersen, Raben Rosenberg and Jens Randel Nyengaard: Estimation of number and volume of immunohistochemically stained neurons in complex brain regionsSection 3: Length11. Stephen M. Evans and Jens Randel Nyengaard: Introduction12. Yong Tang and Jens Randel Nyengaard: Length estimation of nerve fibers in human white matter using isotropic uniformly random sections13. Jytte Overgaard Larsen, M. von Euler and Ann Marie Janson: Virtual test systems for estimation of orientation- dependent parameters in thick, arbitrary oriented sections exemplified by length quantification of regenerating axons in spinal cord lesions using isotropic, virtual planesSection 4: Second order stereology14. Stephen M. Evans: Spatial distributionSection 5: Cell Culture15. Hannsjorg Schroder, Jens Rendel Nyengaard, W. Selberis, E. Lain, A. Keller, C. Kohler and B. Witter: Unbiased morphometrical techniques for the quantitative assessment of cells in primary dissociation cultures