Quasispecies: From Theory To Experimental Systems by Esteban Domingo

Quasispecies: From Theory To Experimental Systems

byEsteban DomingoEditorPeter Schuster

Paperback | April 19, 2018

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This volume brings together recent developments in quasispecies theory extended to variable environments and practical applications in elucidating viral dynamics and treatment designs. In particular, the existence of an error threshold in rugged fitness landscapes has opened the way to a new antiviral strategy termed lethal mutagenesis, which is now under intensive theoretical, experimental and clinical investigation. As such the book explains how an understanding of quasispecies dynamics within infected organisms has increased our knowledge of viral disease events. From a clinical perspective, population dynamics highlights important problems for viral disease control, such as the selection of drug-resistant mutants that often accompanies treatment failures, and suggests means of increasing the effectiveness of antiviral treatments. The book is intended for students and scientists interested in basic and applied aspects of biophysics, chemistry, biology, evolution and medical virology.

Esteban Domingo is a professor at the Spanish Research Council at Centro de Biología Molecular Severo Ochoa (Madrid) and President of the Spanish Society of Virology. He is a member of EMBO and Real Academía de Ciencias Exactas, Físicas y Naturales. Peter Schuster, em. professor of University of Vienna is a membe...
Title:Quasispecies: From Theory To Experimental SystemsFormat:PaperbackProduct dimensions:357 pages, 9.25 X 6.1 X 0 inShipping dimensions:357 pages, 9.25 X 6.1 X 0 inPublished:April 19, 2018Publisher:Springer NatureLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3319795481

ISBN - 13:9783319795485

Appropriate for ages: All ages

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Table of Contents

What is a quasispecies?- Historical origins and current scope.- The nucleation of semantic information in prebiotic matter.- Evolution of RNA-based networks.- Quasispecies on fitness landscapes.- Mathematical models of quasispecies theory and exact results for the dynamics.- Theoretical Models of Generalized Quasispecies.- Theories of lethal mutagenesis: from error catastrophe to lethal defection.- Estimating fitness of viral quasispecies from next-generation sequencing data.- Getting to know viral evolutionary strategies: Towards the next generation of quasispecies models.- Cooperative Interaction within RNA Virus Mutant Spectra.- Arenavirus Quasispecies And Their Biological Implications.- Models of viral population dynamics.- Fidelity variants and RNA quasispecies.- Antiviral strategies based on lethal mutagenesis and error threshold.