Quest for the Cure: The Science and Stories Behind the Next Generation of Medicines

Kobo ebook | May 3, 2011

byBrent Stockwell

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After more than fifty years of blockbuster drug development, skeptics are beginning to fear we may be reaching the end of drug discovery to combat major diseases. In this engaging book, Brent Stockwell, a leading researcher in the exciting new science of chemical biology, describes this dilemma and the powerful techniques that may bring drug research into the twenty-first century.

Filled with absorbing stories of breakthroughs, the book begins with the scientific achievements of the twentieth century that led to today's drug innovations. We learn how the invention of mustard gas in World War led to early anti-cancer agents and how the efforts to decode the human genome might lead to new approaches in drug design. Stockwell then turns to the seemingly incurable diseases we face today, such as Alzheimer's, many cancers, and others with no truly effective medicines, and describes cellular and molecular barriers thwarting scientists who use tools from traditional pharmaceutical research.

Scientists such as Stockwell are now developing methods to combat these complexities—technologies for constructing and testing millions of drug candidates, sophisticated computational modeling, and entirely new classes of drug molecules—all with an eye toward solving the most profound mysteries of living systems and finding cures for intractable diseases. If successful, these methods will unlock a vast terrain of untapped drug targets that could lead to a bounty of breakthrough medicines. Offering a rare, behind-the-scenes look at this cutting-edge research, The Quest for the Cure tells a thrilling story of science, persistence, and the quest underway to develop a new generation of cures.

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From the Publisher

After more than fifty years of blockbuster drug development, skeptics are beginning to fear we may be reaching the end of drug discovery to combat major diseases. In this engaging book, Brent Stockwell, a leading researcher in the exciting new science of chemical biology, describes this dilemma and the powerful techniques that may brin...

Brent R. Stockwell is an associate professor of biological sciences and chemistry at Columbia University and a Howard Hughes Medical Institute Early Career Scientist. He serves on the editorial board of Chemistry & Biology, has been awarded ten U.S. patents, and has published fifty-four scientific papers. Among his recent honors are ...
Format:Kobo ebookPublished:May 3, 2011Publisher:Columbia University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0231525524

ISBN - 13:9780231525527

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Extra Content

Table of Contents

List of Illustrations
Preface
Acknowledgments
Abbreviations
Part I. The Vanishing Cures
1. The Drug Discovery Crisis
2. A New Science of Molecules
3. The Birth of the First Cancer Drugs
4. A New Company Creating Drug Combinations
5. The Undruggable RAS Protein
6. The Druggable Genome
Part II. The Path to the Next Generation of Medicines
7. Peering Inside Proteins
8. The Nature of Interactions Between Proteins
9. From Protein-Protein Interactions to Personalized Medicines
10. A Revolution in Peptide Synthesis
11. A Vast Array of Drug Candidates
12. Moving Outside the Small Molecule Box
13. Accelerating the Arrival of Next-Generation Drugs
Notes
Glossary
Index

Editorial Reviews

It is impossible to read this relatively short book...without being captured by the author's optimism about the future of drug development.