Recent Advances in HTLV Research 2015

Recent Advances in HTLV Research 2015

Paperback | February 24, 2017

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The human T-cell leukemia virus types 1 and 2 (HTLV-1 and HTLV-2) were both discovered over three decades ago and infect millions people worldwide. HTLV-1 is associated with the adult T-cell leukemia/lymphoma (ATLL) in about 2% of individuals infected, and another 2 to 3% of individuals develop a neurologic disorder called HTLV-associated myelopathy (HAM). HTLV-2 causes HAM in approximately 1 to 2% of infected individuals, but does not cause ATLL. HTLV-1 and HTLV-2 have served as excellent models for the study of the epidemiology and pathogenesis of virus-associated cancers as well as autoimmune conditions such as multiple sclerosis. Recently, two new members—HTLV-3 and HTLV-4—have been discovered in bushmeat hunters from central Africa, which emphasizes the urgent need for continual surveillance for new human retroviruses and their capacity to cause disease.

Important public health issues remain open issues to be addressed in spite of the basic epidemiology of HTLV-1 and HTLV-2 being reasonably well defined. Clinical research is needed in developing potential HTLV-1 and HTLV-2 vaccines, as well as development of treatment options for ATLL and HAM. This ‘Recent Advances Issue’ contains both reviews and updates on research that encompasses these areas.

Title:Recent Advances in HTLV Research 2015Format:PaperbackProduct dimensions:308 pages, 9.61 X 6.69 X 0.84 inShipping dimensions:308 pages, 9.61 X 6.69 X 0.84 inPublished:February 24, 2017Publisher:MDPI AGLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3038423769

ISBN - 13:9783038423768

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Table of Contents

Molecular Studies of HTLV-1 Replication: An Update

Recent Advances in BLV Research

From Immunodeficiency to Humanization: The Contribution of Mouse Models to Explore HTLV-1 Leukemogenesis

Molecular Mechanisms of HTLV-1 Cell-to-Cell Transmission

The Role of HBZ in HTLV-1-Induced Oncogenesis

Roles of HTLV-1 basic Zip Factor (HBZ) in Viral Chronicity and Leukemic Transformation.
Potential New Therapeutic Approaches to Prevent and Treat HTLV-1-Related Diseases

Recent Advances in Therapeutic Approaches for Adult T-cell Leukemia/Lymphoma

Transcriptional and Epigenetic Regulatory Mechanisms Affecting HTLV-1 Provirus

The Emerging Role of miRNAs in HTLV-1 Infection and ATLL Pathogenesis

HTLV-1, Immune Response and Autoimmunity

Mother-to-Child Transmission of HTLV-1 Epidemiological Aspects, Mechanisms and Determinants
of Mother-to-Child Transmission

Genetic Markers of the Host in Persons Living with HTLV-1, HIV and HCV Infections

PRMT5 Is Upregulated in HTLV-1-Mediated T-Cell Transformation and Selective Inhibition Alters
Viral Gene Expression and Infected Cell Survival

HTLV-1 Rex Tunes the Cellular Environment Favorable for Viral Replication

Distinct Morphology of Human T-Cell Leukemia Virus Type 1-Like Particles

A Potential of an Anti-HTLV-I gp46 Neutralizing Monoclonal Antibody (LAT-27) for Passive
Immunization against Both Horizontal and Mother-to-Child Vertical Infection with Human T Cell
Leukemia Virus Type-I

Heat Shock Enhances the Expression of the Human T Cell Leukemia Virus Type-I (HTLV-I)
Trans-Activator (Tax) Antigen in Human HTLV-I Infected Primary and Cultured T Cells

Analysis of the Prevalence of HTLV-1 Proviral DNA in Cervical Smears and Carcinomas from HIV
Positive and Negative Kenyan Women

Human T-Lymphotropic Virus Type I (HTLV-1) Infection among Iranian Blood Donors:
First Case-Control Study on the Risk Factors

Low Proviral Load is Associated with Indeterminate Western Blot Patterns in Human T-Cell
Lymphotropic Virus Type 1 Infected Individuals: Could Punctual Mutations be Related?