Recent Progress in Bunyavirus Research

Recent Progress in Bunyavirus Research

Paperback | June 9, 2017

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The Bunyaviridae is the largest family of RNA viruses, with over 350 isolates worldwide distributed into five genera (i.e., Hantavirus, Orthobunyavirus, Nairovirus, Tospovirus, and Phlebovirus). Many of these viruses are significant human or agricultural pathogens. The increasing number of reports on new emerging bunyaviruses and infection episodes makes it essential that we obtain a comprehensive understanding of bunyaviruses and their infection mechanisms. Although all bunyaviruses possesses a tripartite, negative-sense (or ambi-sense) RNA genome, they exhibit substantial differences in their structure, genome organization and replication strategies, which make functional interpolation across genus boundaries difficult.

Fortunately, the bunyavirus field has witnessed many exciting new findings and breakthroughs in recent years. These discoveries span a wide spectrum of research areas, including structural characterization of viruses and viral proteins, the identification of new viruses, investigations into host switch and vectors of transmission, genome-based analysis of virus evolution and phylogenetic lineages, the development of new research tools, such as replicons and reverse genetics, molecular characterization of the virus life cycle at the cell level (i.e., cell entry, replication, transcription, translation, genome packaging, reassortment, and virus assembly, etc.), studies of virus–host interactions and host antiviral defense, the development of vaccines/drugs and the use of bunyaviruses for novel applications.

This book includes both research and review papers that together provide a glimpse into the latest research on bunyaviruses and, at the same time, highlight some of the important research achievements made in recent years. Study topics of both a fundamental and applied nature are collated. An informed perspective for future research directions is provided and can stimulate research in some of the understudied areas.

Title:Recent Progress in Bunyavirus ResearchFormat:PaperbackProduct dimensions:232 pages, 9.61 X 6.69 X 0.63 inShipping dimensions:232 pages, 9.61 X 6.69 X 0.63 inPublished:June 9, 2017Publisher:MDPI AGLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3038423920

ISBN - 13:9783038423928

Appropriate for ages: All ages

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Table of Contents

1) Homage to Richard M. Elliott
2) Genomic Characterization of the Genus Nairovirus (Family Bunyaviridae)
3) Genetic and Phylogenetic Characterization of Tataguine and Witwatersrand Viruses and Other Orthobunyaviruses of the Anopheles A, Capim, Guamá, Koongol, Mapputta, Tete, and Turlock Serogroups
4) Mutational Analysis of the Rift Valley Fever Virus Glycoprotein Precursor Proteins for Gn Protein Expression
5) N-Glycans on the Rift Valley Fever Virus Envelope Glycoproteins Gn and Gc Redundantly Support Viral Infection via DC-SIGN
6) The Role of Phlebovirus Glycoproteins in Viral Entry, Assembly and Release
7) Conserved Endonuclease Function of Hantavirus L Polymerase
8) Early Bunyavirus-Host Cell Interactions
9) What Do We Know about How Hantaviruses Interact with Their Different Hosts?
10) Molecular Insights into Crimean-Congo Hemorrhagic Fever Virus
11) What Do We Know about How Hantaviruses Interact with Their Different Hosts?
12) Phleboviruses and the Type I Interferon Response
13) Making Bunyaviruses Talk: Interrogation Tactics to Identify Host Factors Required for Infection