Receptor Chemistry Towards the Third Millennium

Other | May 1, 2000

byGianella, M., M. Gianella

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Receptor Chemistry Towards the Third Millennium is the result of papers presented at the 12th Camerino-Noordwijkerhout Symposium, held in Camerino, Italy in September 1999. Although much is known about the way ligands interact with receptors, which have now been isolated, characterized and cloned, many aspects still remain to be explored. In particular, differentiation into distinct subpopulations and the multiplicity of transduction processes offer more specific targets in the search for new drugs.


This book will be of interest to medicinal chemists, pharmacologists, biochemists and neurologists and will also be a valuable source of reference for medical students and postgraduate students in related fields.

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Receptor Chemistry Towards the Third Millennium is the result of papers presented at the 12th Camerino-Noordwijkerhout Symposium, held in Camerino, Italy in September 1999. Although much is known about the way ligands interact with receptors, which have now been isolated, characterized and cloned, many aspects still remain to be explor...

Format:OtherDimensions:280 pages, 1 × 1 × 1 inPublished:May 1, 2000Publisher:Elsevier ScienceLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0080540406

ISBN - 13:9780080540405

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Table of Contents

Abbreviated Contents:Pharmacological receptors: A century of discovery - and more (D.J. Triggle). Cholinergic receptors and neurodegenerative diseases (F. Gualtieri). Central nicotinic receptor ligands and pharmacophores (R.A. Glennon). Recombinant human receptors and functional assays in the discovery of novel acetylcholine-gated ion channel (nAchR)Agonist (N.D.P. Cosford). Design and development of selective muscarinic agonists for the treatment of alzheimer's disease (W.S. Messer). Cl-1017 a functionally M1 selective muscarinic agonist: design synthesis and preclinical pharmacology (H. Tecle). Receptors in cardiovascular disease: review and introduction (A. Leonardi). Adrenoceptor subclassification: an approach to improved cardiovascular therapeutics (J.P. Hieble). Selection design and evaluation of new radioligands for pet studies of cardiac adrenoceptors (V.W. Pike). Imidazoline receptors: A challenge (P. Bosquet). Sigma receptors: recent advances and new clinical potentials (W. Bowen). Excitatory amino acid agonists and antagonists: Pharmacology and therapeutic applications (D. Trist). Metabotropic glutamate receptors: A structural view point (R. Pellicciari). Introduction to receptors in neurodegenerative diseases (W. Froestl). Neurotrophin receptor structure and interactions (M.V. Chao). The ciliary neurotrophic factor (CNTIF) and its receptor CNTIFR alpha (M. Sleeman ). Rediscovering good old friend IGF-1 in the new millennium (R. Quirion). ICAM-1 receptors and cold viruses (J. Bella). Viral-encoded G-protein coupled receptors: new targets for drug research? (M.J. Smit). General topics and perspectives (H. Timmerman). Pharmacological evidence of muscarinic receptor heterodimerization (R. Maggio). Constitutive activity of G protein coupled receptors and drug action (R. Leurs). Kappa opioid agonists as targets for pharmacotherapies in cocaine abuse (J.L. Neumeyer).