Recombinant Antibodies for Cancer Therapy: Methods and Protocols by Martin WelschofRecombinant Antibodies for Cancer Therapy: Methods and Protocols by Martin Welschof

Recombinant Antibodies for Cancer Therapy: Methods and Protocols

EditorMartin Welschof, Jürgen Krauss

Paperback | October 8, 2011

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In Recombinant Antibodies for Cancer Therapy: Methods and Protocols, Martin Welschoff and Jürgen Krauss present a collection of carefully selected protocols for the design, construction, and characterization of novel anticancer therapeutics based on recombinant antibody technology. These readily reproducible methods include coverage of hybridoma-derived recombinant antibodies, recombinant antibody fragments from phagemid-displayed antibody repertoires, antibody fragments with additional properties, and large-scale production of recombinant antibodies for clinical applications. Concise review articles also survey the current status of recombinant antibodies in cancer therapy, as well as the generation of antibody molecules through antibody engineering.
Title:Recombinant Antibodies for Cancer Therapy: Methods and ProtocolsFormat:PaperbackDimensions:498 pages, 9.02 × 5.98 × 0.01 inPublished:October 8, 2011Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617372501

ISBN - 13:9781617372506

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Table of Contents

Part I. IntroductionGeneration of Antibody Molecules Through Antibody EngineeringSergey M. KipriyanovApplication of Recombinant Antibodies in Cancer PatientsJürgen Krauss, Michaela Arndt, and Michael PfreundschuhPart II. Hybridoma-Derived AntibodiesDNA Immunization as a Means to Generate Antibodies to ProteinsPartha S. ChowdhuryChimerization of a Monoclonal Antibody for Treating Hodgkin's LymphomaJürgen Krauss, Hans Heinrich Förster, Barbara Uchanska-Ziegler, and Andreas ZieglerHumanization of Monoclonal Antibodies by CDR GraftingSiobhan O'Brien and Tarran JonesPart III. Recombinant Antibody Fragments from Phagemid-Displayed Antibody RepertoiresGeneration and Screening of a Modular Human scFv Expression Library from Mulitple DonorsMartin Welschof, Christiane Christ, Ingrid Hermes, Armin Keller, Christian Kleist, and Michael BraunagelConstruction of Semisynthetic Antibody LibrariesMichael BraunagelSingle-Domain VH Antibody Fragments from a Phage Display LibraryLiat Binyamin, Daniel Plaksin, and Yoram ReiterIsolation of Human Fab Fragments Against Ovarian Carcinoma Using Guided SelectionMariangela Figini, Andrew Green, Francesco Colotta, and Silvana CanevariHuman Recombinant Fab Antibodies with T-Cell Receptor-Like Specificities Generated from Phage Display LibrariesJan Engberg, Ali F. Yenidunya, Rikke Clausen, Liselotte B. Jensen, Peter Sørensen, Pernille Kops, and Erik RiiseEngineering Hot Spots for Affinity Enhancement of AntibodiesPartha S. ChowdhurySimultaneous Humanization and Affinity Optimization of Monoclonal AntibodiesHerren WuTailoring Kinetics of Antibodies Using Focused Combinatorial LibrariesHerren Wu and Ling-Ling AnPart IV. Antibody Fragments with Additional PropertiesEngineering scFvs for Improved StabilityPartha S. Chowdhury and George VasmatzisRecombinant Single-Chain and Disulfide-Stabilized Fv Immunotoxins for Cancer TherapyRevital Niv, Dina Segal, and Yoram ReiterGeneration of Recombinant Immunotoxins for Specific Targeting of Tumor-Related Peptides Presented by MHC MoleculesCyril J. Cohen, Galit Denkberg, Dina Segal, and Yoram ReiterConstruction and Characterization of RNase-Based Targeted TherapeuticsDianne L. Newton, Junichiro Futami, Dale Ruby, and Susanna M. RybakBispecific Diabodies for Cancer TherapyMichaela Arndt and Jürgen KraussGeneration and Characterization of Bispecific Tandem Diabodies for Tumor TherapySergey M. KipriyanovGeneration of Recombinant Multimeric Antibody Fragments for Tumor Diagnosis and TherapyBarbara E. Power, Alexander A. Kortt, and Peter J. HudsonConstruction and Characterization of Minibodies for Imaging and Therapy of Colorectal CarcinomasPaul J. Yazaki and Anna M. WuGeneration, Expression, and Monitoring of Recombinant Immune Receptors for Use in Cellular ImmunotherapyAndreas Hombach, Claudia Heuser, and Hinrich AbkenTailoring Natural Effector Functions: Antibody Engineering Beyond HumanizationOle H. Brekke and John E. ThommesenSingle-Chain Fv-Based Affinity Purification of the Cellular Stress Protein gp96 for Vaccine DevelopmentChristian Kleist, Daniele Arnold-Schild, Martin Welschof, Martina Finger, Gerhard Opelz, Hans-Georg Rammensee, Hansjörg Schild, and Peter TernessRecombinant Adenoviruses for In Vivo Expression of Antibody FragmentsRoland E. Kontermann, Tina Korn, and Valérie JérômePart V. Large Scale Production of Recombinant Antibodies for Clinical ApplicationProduction of Antibody Fragments in a BioreactorHalldis Hellebust.Large Scale Production of Recombinant Antibodies by Utilizing Cellulose-Binding DomainsItai Benhar and Yevgeny BerdichevskyProduction of Tumor-Specific Antibodies in TobaccoCarmen Vaquero-Martin and Rainer FischerIndex

Editorial Reviews

"...the book is well written and the experimental protocols that were included are described in great detail...this book is a valuable resource both for persons new to this field to get an overview of current activities and for those already in the field to look up specific areas that are covered." -Clinical Immunology"Overall the book is a helpful resource, especially for molecular biologists involved in generating antibody fragments, collecting up to date protocols in one convenient volume." - Pharmaceutical Research