Reelin Glycoprotein: Structure, Biology and Roles in Health and Disease

Hardcover | June 23, 2008

EditorS.H. Fatemi

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Reelin glycoprotein is a serine protease with important roles in embryogenesis and during adult life. This comprehensive and integrative book examines the role that reelin plays in the etiology of various neuropsychiatric disorders, including schizophrenia and autism. The book provides an unprecedented analysis of this emerging and novel protein by examining evidence from genetic, neuroanatomic, biochemical, and behavioral studies.

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From the Publisher

Reelin glycoprotein is a serine protease with important roles in embryogenesis and during adult life. This comprehensive and integrative book examines the role that reelin plays in the etiology of various neuropsychiatric disorders, including schizophrenia and autism. The book provides an unprecedented analysis of this emerging and nov...

From the Jacket

Reelin glycoprotein is a major secretory protein with important roles in embryogenesis and during adult life. Reelin gene mutations or deficiency of the protein product cause abnormal cortical development and reelin signaling impairment in brain. Since the first discovery of the reelin mutant mouse in 1951 by Falconer, and later discov...

Format:HardcoverDimensions:468 pages, 9.25 × 6.1 × 0.03 inPublished:June 23, 2008Publisher:Springer New YorkLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0387767606

ISBN - 13:9780387767604

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Table of Contents

The Reelin Gene and Its Functions in Brain DevelopmentCheng-Chiu Huang, MSGabriella D'Arcangelo, PhD*Apolipoprotein E Receptor 2 and Very Low Density Lipoprotein Receptor: An OverviewDr. Hans H. Bock*Prof. Dr. Joachim HerzChemistry of ReelinYves Jossin, PhD*The C-terminal region of Reelin: structure and functionMitsuharu Hattori, PhD*Crystal Structure of Reelin RepeatsJunichi Takagi, PhD*Comparative Anatomy and Evolutionary Roles of ReelinGundela Meyer, MD, PhD*Reelin / Dab1 Signaling in the Developing Cerebral CortexEric C. Olson, PhD*Christopher A. Walsh, MD, PhDUltrastructural Localization of Reelin Rosalinda C. Roberts, PhD*Emma Perez-Costas, PhDReelin and Cyclin-Dependent Kinase 5Toshio Ohshima, MD, PhD*Reelin and the CerebellumRobert F. Hevner, MD, PhD*Reelin and Radial Glial CellsEckart Forster, PhDShanting Zhao, MDMichael Frotscher, MD*Reelin and CognitionShenfeng Qiu, PhDEdwin John Weeber, PhD*Protein Kinases and Signaling Pathways that are Activated by ReelinJonathan A. Cooper, PhD*Nathaniel S. Allen, BSLibing Feng, PhDThe Relationship of Oxytocin and Reelin in the BrainGeorge D. Pappas, PhD*C. Sue Carter, PhDReelin and Thyroid HormoneManuel Alvarez-Dolado, PhD*A Tale of Two Genes: Reelin and BDNFThomas Ringstedt, PhD*Reelin, Liver, and LymphaticsBrigitte Samama, PhD*Nelly Boehm, MD, PhDReelin and Cajal-Retzius CellsJean-Marc Mienville, PhD*Reelin and OdontogenesisFrancoise Bleicher*Henry MagloireMarie-Lise CoubleJean-Christophe MaurinHomozygous and Heterozygous Reeler Mouse MutantsPatricia Tueting, PhD*Graziano Pinna, PhDErminio Costa, MDReelin and LissencephalyElena Parrini, PhDRenzo Guerrini, MD*The Role of Reelin in Etiology and Treatment of Psychiatric DisordersS. Hossein Fatemi, MD, PhD*Teri J. Reutiman, BATimothy D. Folsom, MSReelin Downregulation as a Prospective Treatment Target for GABAergic Dysfunction in SchizophreniaErminio Costa, MD*Ying Chen, PhDErbo Dong PhDDennis R. Grayson, PhDAlessandro Guidotti, MDMarin Veldic, MDEpigenetic Modulation of Reelin Function in Schizophrenia and Bipolar DisorderHamid Mostafavi Abdolmaleky, MD*Cassandra L. Smith PhDJin-Rong Zhou, PhDSam Thiagalingam, PhDReelin Gene Polymorphisms in Autistic DisorderCarla Lintas PhDAntonio Maria Persico, MD*Alzheimer's and ReelinArancha Botella-Lopez, BSJavier Saez-Valero, PhD*Reelin and StrokeKunlin Jin, MD, PhD*Reelin and Pancreatic Cancer                    Kimberly Walter, BS                    Michael Goggins, MD*

Editorial Reviews

From the reviews:"The glycoprotein reelin, involved in a multitude of important neurobiological processes including embryogenesis and brain development, is the focus of this informative and interesting book. . The intended audience includes researchers in the field and clinicians. Clinicians who are interested in understanding the importance of epigenetic factors involved in neuropsychiatric disorders would be find this book helpful. . This is an excellent summary of the current state of research findings on this putatively important glycoprotein." (Michael J. Schrift, Doody's Review Service, July, 2009)"The whole book is dedicated just to one biopolymer, reelin, which is a major secretory glycoprotein with biological activity in various processes of our body. . The book consists of 28 chapters presented by international group of experts. . book will be very useful as foundation for analysis of this emerging novel glycoprotein for biochemists, molecular biologists, neuroscientists, and clinicians specialized in psychiatric disorders." (G. Ya. Wiederschain, Biochemistry, Vol. 75 (5), 2010)