Regenerative Nephrology

Other | November 26, 2010

byMichael S. Goligorsky, Michael S. Goligorsky

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Progression of chronic diseases in general and chronic kidney disease in particular has been traditionally viewed in the light of various contributors to development of glomerulosclerosis and tubulointerstitial scarring culminating in renal fibrosis. Indeed, this dogma prevailed for decades underscoring experimental attempts to halt fibrotic processes. Breakthrough investigations of the past few years on stem/progenitor cell involvement in organ regeneration caused a conceptual shift in tackling the mechanisms of nephrosclerosis. It has become clear that the rate of progression of chronic kidney disease is the net sum of the opposing trends: degenerative fibrotic processes and regenerative repair mechanisms. The latter part of this equation has been by and large ignored for years and only recently attracted investigative attention. This book revisits the problem of kidney disease by focusing on regenerative mechanisms in renal repair and on the ways these regenerative processes can become subverted by an intrinsic disease process eventuating in its progression. Cutting-edge investigations are summarized by the most experienced international team of experts.

  • Presents a comprehensive, translational source for all aspects of renal stem cells, tissue regeneration, and stem cell therapies for renal diseases in one reference work. This will ultimately result in time savings for academic, medical and pharma researchers
  • Experts in the renal stem cell system in kidney repair and regeneration take readers from the bench research to new therapeutic approaches, providing a common language for nephrology researchers, fellows and other stem cell researchers. This enables the discussion of development of stem cells and their use in the repair and regeneration of the kidney

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From the Publisher

Progression of chronic diseases in general and chronic kidney disease in particular has been traditionally viewed in the light of various contributors to development of glomerulosclerosis and tubulointerstitial scarring culminating in renal fibrosis. Indeed, this dogma prevailed for decades underscoring experimental attempts to halt fi...

Format:OtherDimensions:442 pages, 1 × 1 × 1 inPublished:November 26, 2010Publisher:Elsevier ScienceLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0123809290

ISBN - 13:9780123809292

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Table of Contents

PHYLOGENY AND ONTOGENY OF TISSUE REGENERATION

  1. Glomerulogenesis and de novo nephrogenesis in medaka fish - evolutionary approach
  2. Yuko Wakamatsu and Hisashi Hashimoto

  3. Renal Organogenesis: Growing a replacement kidney in situ from transplanted renal primordia
  4. Marc R. Hammerman

  5. Use of Genetic Mouse Models to study Kidney Regeneration
  6. Akio Kobayashiand Jeremy S. Duffield

    MEDIATORS OF REGENERATION

  7. Endogenous Anti-Inflammatory and Pro-Resolving Lipid Mediators in Renal Disease
  8. Charles N. Serhan and Catherine Godson

  9. Tissue protection and regeneration aided by erythropoietin and erythropoietin-derived peptides Danilo Fliser
  10. Mast cells in kidney regeneration
  11. Eric Daugas, Walid Beghdadiand Ulrich Blank

  12. Role of macrophages in renal injury, repair and regeneration
  13. Vincent Lee, Qi Cao, Yiping Wang and David C.H. Harris

  14. T-cells contribution to regenerative processes
  15. Hamid Rabb

    STEM CELLS IN REGENERATIVE PROCESSES

  16. MSC and reparative processes
  17. Benjamin D. Humphreys and John V. Bonventre

  18. Stem cells in regenerative processes: Endothelial progenitor cells and the kidney
  19. Matthieu Monge, Anton J. van Zonneveld and Ton J. Rabelink

  20. The potential of the side population in regenerative nephrology
  21. Melissa H. Little and G. A. Challen

  22. Very small embryonic like stem cells (VSELs) and their potential relevance for kidney homeostasis
  23. Dong-Myung Shin, Rui Liu, Janina Ratajczak, Magda Kucia and Mariusz Z. Ratajczak

  24. Stem Cells in Regenerative Processes; Induced Pluripotent Stem Cells
  25. Kenji Osafuneand Shinya Yamanaka

  26. Methods of Isolation and Culture of Adult Stem cells
  27. Lindolfo da Silva Meirelles and Nance Beyer Nardi

    STEM CELLS - FROM THE NICHE TO REPAIR

  28. Stem cell niche in the kidney
  29. Laura Lasagni, Elena Lazzeri and Paola Romagnani

  30. Creation of artificial niches
  31. Glenn D. Prestwich,Tammer Ghaly, Philip Brudnicki, Brian Ratliffand Michael S. Goligorsky

  32. Imaging of transplanted and native stem cells
  33. Xiang-Yang Zhu, Martin Rodriguez-Porcel and Lilach O. Lerman

    CAUSES OF REGENERATIVE FAILURE

  34. Stem cell injury and premature senescence
  35. Michael S. Goligorsky

  36. Regeneration and Aging: Regulation by Sirtuins and the NAD+Salvage Pathway
  37. Nica M. Borradaile, Alanna Watson, and J. Geoffrey Pickering

  38. BONE MARROW-MESENCHYMAL STEM CELLS IN ORGAN REPAIR AND STRATEGIES TO OPTIMIZE THEIR EFFICACY
  39. Christodoulos Xinaris, Barbara Imberti, Giuseppe Remuzzi and Marina Morigi

    EMERGING CLINICAL ASPECTS OF STEM CELL THERAPY

  40. Treatment of Acute Kidney Injury with allogeneic Mesenchymal Stem Cells: Preclinical and initial Clinical Data
  41. Florian E. Tögel and Christof Westenfelder

  42. Clinical trials in Renal Regenerative Medicine
  43. Maarten B. Rookmaaker, Jaap A. Joles and Marianne C. Verhaar

  44. Potential risks of stem cell therapies
  45. Uta Kunter and Jürgen Floege

  46. Tissue engineering in urology
  47. Anthony Atala

  48. Ethical issues in SC therapy
  49. Donald W. Landry

  50. Stem Cell Banking

Vicente Mirabet and Pilar Solves