Regulation of Gene Expression in the Tumor Environment: Regulation of melanoma progression by the microenvironment: the roles of PAR-1 and PAFR by Menashe Bar-EliRegulation of Gene Expression in the Tumor Environment: Regulation of melanoma progression by the microenvironment: the roles of PAR-1 and PAFR by Menashe Bar-Eli

Regulation of Gene Expression in the Tumor Environment: Regulation of melanoma progression by the…

byMenashe Bar-Eli

Paperback | November 30, 2010

Pricing and Purchase Info

$344.95

Earn 1,725 plum® points

Prices and offers may vary in store

Quantity:

In stock online

Ships free on orders over $25

Not available in stores

about

It is now becoming very clear that the development and progression of tumor towards the malignant (metastatic) phenotype depends tightly on the interaction between the tumor cells and the tumor microenvironment. Tumor cells respond to stimuli generated within the tumor microenvironment for their growth advantage while the tumor cell themselves reshape and remodel the architecture and function of their extracellular matrices. The term tumor microenvironment is a wide umbrella consisting of stromal cells such as fibroblasts and endothelial cells and infiltration immune cells including T and B cells, macrophages, and other inflammatory cells (PMNs). These different components of the tumor microenvironment could have stimulatory and inhibitory effects on tumor progression by regulating the gene expression repertoire within the tumor cells on one hand and the stroma cells on the other. In this volume we have seven contributors who will discuss several different aspects on the cross talk within the tumor microenvironment components leading to the acquisition of the metastatic phenotype. It is our hope that these state-of-the-art studies will shed further light on our understanding of these complicated processes.

Title:Regulation of Gene Expression in the Tumor Environment: Regulation of melanoma progression by the…Format:PaperbackDimensions:148 pagesPublished:November 30, 2010Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:9048178495

ISBN - 13:9789048178490

Look for similar items by category:

Reviews

Table of Contents

Preface Chapter 1: Regulation of Melnoma Progression by the Tumor Microenvironment: the Roles of PAR-1 and PAFR. Gabriel J. Villares and Menashe Bar-Eli Chapter 2: Functions of Autocrine Motility Factor at the Tumor Microenvironment. Tatsuyoshi Funasaka and Avraham Raz Chapter 3: Targeting Signaling Pathways - in the search of Melanoma's Achilles' heel. Nikolas K. Haass, Christoph Hoeller and Meenhard Herlyn Chapter 4: Regulation of Gene Expression in Tumor and Non-Tumor Cells in the Tumor Microenvironment. Impact of ErbB2 Over-Expression on Tumor and Tumor Microenvironment that facilitate tumor progression and metastasis. Valerie Stone Hawthorne and Dihua Yu Chapter 5: Intercellular and Cytoskeletal Signaling Converge at PAK's. Anupama E. Gururaj and Rakesh Kumar Chapter 6: Molecular Basis for Vascular Endothelial Growth Factor Expression Tumor. Keping Xie and James Yao Chapter 7: Incipent Event in Human carcinogenesis: A Concept of Forerunner Genes. Bogdan Czerniak