Regulation of Vertebrate Limb Regeneration

Hardcover | April 30, 1999

EditorRaymond E. Sicard

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The regenerating vertebrate limb is an excellent model for exploring a number of significant questions in developmental biology. Written by leading investigators in the field, this collection provides a comprehensive discussion of the roles played by the major regulators affecting limbregeneration and repair following trauma. Using the amphibian limb as the recognized model system, the contributors explore in detail the contributions made by biopotentials, the skin, the endocrine system, and nerves in regulating such events as dedifferentiation, the proliferation of blastemacells , and pattern formation. The modulating roles of blood cells and the immune system are re-examined, and the exciting studies on the isolation and characterization of neurotropic factors reviewed. The sometimes provocative but always informative and up-to-date discussions provided in thisvolume will be of particular interest to developmental biologists, anatomists, neuroscientists, and cell biologists.

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The regenerating vertebrate limb is an excellent model for exploring a number of significant questions in developmental biology. Written by leading investigators in the field, this collection provides a comprehensive discussion of the roles played by the major regulators affecting limbregeneration and repair following trauma. Using the...

Format:HardcoverDimensions:195 pages, 9.56 × 6.38 × 0.66 inPublished:April 30, 1999Publisher:Oxford University Press

The following ISBNs are associated with this title:

ISBN - 10:0195036042

ISBN - 13:9780195036046

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Table of Contents

1. Raymond E. Sicard: Introduction and Overview2. Richard B. Borgens: Natural Voltage Gradients and the Generation and Regeneration of Limbs3. David L. Stocum: The Role of the Skin in Urodele Limb Regeneration4. Richard A. Liversage, Danielle S. McLaughlin, and Hooley M. G. McLaughlin: The Hormonal Milieu in Amphibian Appendage Regeneration5. Roy A. Tassava and Cherie L. Olsen: Neurotrophic Influence on Cellular Proliferation in Urodele Limb Regeneration: in vivo experiments6. Robert L. Carlone and Anthony L. Mescher: Trophic Factors from Nerves7. Morton Globus and Swani Vethamany-Globus: In Vitro Studies of Controlling Factors in Newt Limb Regeneration8. Raymond E. Sicard: Leukocytic and Immunological Influence on Regeneration of Amphibian Forelimbs9. Raymond E. Sicard: Synopsis and ConclusionReferencesIndex

Editorial Reviews

"The perspectives and information contained in Regulations of Limb Regeneration will help to advance understanding of the current research being conducted in this field."--Biology Digest