Regulatory T Cells and Clinical Application by Shuiping JiangRegulatory T Cells and Clinical Application by Shuiping Jiang

Regulatory T Cells and Clinical Application

EditorShuiping Jiang

Hardcover | October 6, 2008

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The immune system reacts vigorously to foreign invaders such as viruses, bacteria, protozoa, and parasites, and yet shows unresponsiveness to our own proteins. Immune tolerance to self-proteins is paramount to prevent the development of autoimmune disease. In the past decade, several types of T lymphocytes in the immune system have been discovered to function as regulatory cells to suppress unwanted immune responses to self-proteins, leading to the protection of autoimmunity. Furthermore, regulatory T cells also protect us from the development of asthma allergy, and prevent organ transplantation rejection. Regulatory T Cells and Clinical Application provides a comprehensive view of all types of regulatory T cells described so far in the literature. By thoroughly reviewing the immunobiology of regulatory T cells and their implications in various forms of human diseases, a new perspective of therapy using regulatory T cells as individualized medicine to treat inflammatory diseases including diabetes, allergy and transplantation rejection is highlighted.About the Editor:Dr. Shuiping Jiang is a British Heart Foundation Fellow in the Department of Nephrology and Transplantation at Guy's Hospital, King's College London, United Kingdom.
Title:Regulatory T Cells and Clinical ApplicationFormat:HardcoverDimensions:608 pagesPublished:October 6, 2008Publisher:Springer New YorkLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0387779086

ISBN - 13:9780387779089

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Table of Contents

Preface by Ethan M. Shevach, National Institute of Health, USA.- Part One: Immunobiology of Regulatory T Cells.- Regulatory T cells and the control of auto-immunity: from day 3 thymectomy to FoxP3+ regulatory T cells by Makoto Miyara and Shimon Sakaguchi, Kyoto University, Japan.- FoxP3 and regulatory T cells by Karsten Kretschmer, Irina Apostolou, Panos Verginis and Harald von Boehmer, Harvard University.- Thymic and peripheral generation of CD4+CD25+FoxP3+ regulatory T cells by Paola Romagnoli, Julie Ribot, Julie Tellier and Joost P.M. van Meerwij, INSERM, France.- The role of IL-2 in the development and peripheral homeostasis of naturally occurring CD4+CD25+Foxp3+ regulatory T cells by Allison L. Bayer and Thomas R. Malek, University of Miami, USA.- IL-2 signaling and CD4+CD25+ regulatory T cells by Louise M. D'Cruz and Ludger Klein, University of Vienna, Austria.- TGF-b and regulatory T cells by Yisong Y. Wan and Richard Flavell, Yale University, USA.- TGF-b controls reciprocal differentiation of CD4+CD25+FoxP3+ regulatory T cells and IL-17 producing Th17 cells from naïve CD4+CD25- T cells by Wanjun Chen, National Institute of Health, USA.- Molecular signalling in regulatory T cells (by Natasha R. Locke, Natasha K. Crellin and Megan K. Levings, University of British Columbia, Canada.- Part Two: Regulatory T Cells in Disease and Clinical Application.- CD4+FoxP3+ regulatory T cells in immune tolerance by Ciriaco A. Piccirillo, McGill University, Canada.- Regulatory T cell control of autoimmune diabetes and their potential therapeutic application by Qizhi Tang and Jeffrey A. Bluestone, University of California at San Francisco, USA.- CD4+CD25+ regulatory T cells as adoptive cell therapy for autoimmune disease and for the treatment of graft-versus-host disease by Swati Acharya and C. Garrison Fathman, Stanford University, USA.- Natural CD4+CD25+ regulatory T cells in regulation of autoimmune disease by Adam P. Kohm and Stephen D. Miller, Northwestern University, USA.- Multiple sclerosis and regulatory T cells by Jonathon Hutton, Clare Baecher-Allan and David A. Hafler, Harvard University, USA.- CD4+CD25+ regulatory T cells and TGF-b in mucosal inflammation by M. Fantini and Markus F. Neurath, University of Mainz, Germany.- Induction of adaptive CD4+CD25+FoxP3+ Regulatory T cell response for autoimmune disease by Jian Hong, Sheri Skinner and Jingwu Zhang, Shanghai Institutes of Biological Sciences, China.- Regulatory T cells in transplantation by Kathryn J Wood, Andrew Bushell, Manuela Carvalho-Gaspar, Gang Feng, Ross Francis, Nick Jones, Elaine Long, Shiqiao Luo, Ian Lyons, Satish Nadig, Birgit Sawitzki, Gregor Warnecke, Bin Wei and Joanna Wieckiewicz, University of Oxford, the UK.- Regulatory T-cells in therapeutic transplantation tolerance by Herman Waldmann, Elizabeth Adams, Paul Fairchild and Stephen Cobbold, University of Oxford, the UK.- CD4+CD25+ regulatory T cell therapy for the induction of clinical transplantation tolerance by David S. Game, Robert I. Lechler and Shuiping Jiang, King's College London, the UK.- Regulatory T cells in allergic disease by Catherine Hawrylowicz, King's College London, the UK.- Regulatory T cells and tumour immunotherapy by Ilona Kryczek and Weiping. Zou, University of Michigan, USA.- Regulatory T cells in hepatitis and hepatocellular carcinoma by Fu-Sheng Wang and George F. Gao, Beijing Institute of Infectious Diseases, China.- CD4+CD25+ regulatory T cells in viral infections by Wayne A. Tompkins, Mary B. Tompkins, Angela M. Mexas and Jonathan E. Fogle, North Carolina State University, USA.- IL-10 and TGF-b-producing regulatory T cells in infection by P. J. Dunne, A. G. Rowan, J. M. Fletcher and Kingston H. G. Mills, Trinity College, Ireland.- Human type 1 T regulatory cells by Manuela Battaglia, Silvia Gregori, Rosa Bacchetta and Maria Grazia Roncarolo, San Raffaele Institute, Italy.- CD8+ regulatory T cells in eye derive tolerance by Joan Stein-Streilein and Hiroshi Keino, Harvard University, USA.- Immune suppression by a novel population of CD8aa+TCRab+ regulatory T cells by Trevor R. F. Smith and Vipin Kumar, Torrey Pines Institute for Molecular Studies, USA.- Innate regulatory iNKT cells by Dalam Ly and Terry L. Delovitch, Robarts Research Institute, Canada.- Natural killer T cells regulate the development of asthma by Muriel Pichavant, Rosemarie H. DeKruyff, and Dale T. Umetsu, Harvard University, USA.- The development, activation, function and mechanisms of immunosuppressive double negative (DN) T cells by Megan S. Ford and Li Zhang, University of Toronto, Canada.- gd T cells in immunoregulation by Long Tang, Ning Kang and Wei He, Chinese Academy of Medical Sciences, China.-