Replication-Competent Reporter-Expressing Viruses by Luis Martinez-SobridoReplication-Competent Reporter-Expressing Viruses by Luis Martinez-Sobrido

Replication-Competent Reporter-Expressing Viruses

EditorLuis Martinez-Sobrido

Hardcover | October 31, 2016

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Recombinant viruses expressing reporter fluorescent or bioluminescent proteins are an excellent option to evaluate the dynamics of viral infection progression in both cultured cells and/or validated animal models of viral infection. Reporter proteins are valid surrogates for direct detection of infected cells in vitro and in vivo, without the use of secondary methodologies to identify infected cells. By eliminating the need of secondary labeling, tractable replicating-competent, reporter-expressing viruses provide an ideal approach to monitor viral infections in real time, representing a significant advance in the study of the biology of viruses, to evaluate vaccination approaches, and to identify new therapeutics against viral infections using high-throughput screening settings. In this Special Issue “Replication-Competent Reporter-Expressing Viruses” we review replication-competent, reporter-expressing viruses belonging to different families, methods of characterization, and applications to facilitate the study of in vitro and in vivo viral infections. We also seek to discuss disadvantages and limitations associated with these reporter-expressing viruses. Finally, we provide rational future perspectives and additional avenues for the development, characterization, and applications of recombinant, reporter-expressing, competent viruses.

Title:Replication-Competent Reporter-Expressing VirusesFormat:HardcoverDimensions:338 pages, 9.61 × 6.69 × 1.06 inPublished:October 31, 2016Publisher:MDPI AGLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3038422584

ISBN - 13:9783038422587

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Table of Contents

1) Fluorescent Protein-Tagged Sindbis Virus E2 Glycoprotein Allows Single ParticleAnalysis of Virus Budding from Live Cells2) Efficient Co-Replication of Defective Novirhabdovirus3) Recombinant Pseudorabies Virus (PRV) Expressing Firefly Luciferase EffectivelyScreened for CRISPR/Cas9 Single Guide RNAs and Antiviral Compounds4) Development of a Triple-Color Pseudovirion-Based Assay to Detect NeutralizingAntibodies against Human Papillomavirus5) Dengue Virus Reporter Replicon is a Valuable Tool for Antiviral Drug Discoveryand Analysis of Virus Replication Mechanisms6) Applications of Replicating-Competent Reporter-Expressing Viruses in Diagnosticand Molecular Virology7) Engineering Hepadnaviruses as Reporter-Expressing Vectors: Recent Progress andFuture Perspectives8) Use of Reporter Genes in the Generation of Vaccinia Virus-Derived Vectors9) Marburg Virus Reverse Genetics Systems10) Replication-Competent Influenza A Viruses Expressing Reporter Genes11) Development of Neutralization Assay Using an eGFP Chikungunya Virus12) Newcastle Disease Virus as a Vaccine Vector for Development of Human andVeterinary Vaccines13) Recombinant Ranaviruses for Studying Evolution of Host-Pathogen Interactionsin Ectothermic Vertebrates14) Reporter-Expressing, Replicating-Competent Recombinant Arenaviruses15) Fluorescent and Bioluminescent Reporter Myxoviruses