Reverse Transcriptase Inhibitors in HIV/AIDS Therapy by Gail SkowronReverse Transcriptase Inhibitors in HIV/AIDS Therapy by Gail Skowron

Reverse Transcriptase Inhibitors in HIV/AIDS Therapy

EditorGail Skowron, Richard Ogden

Paperback | November 19, 2010

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A magisterial survey of all aspects of the reverse transcriptase inhibitors (RTIs) used to treat HIV/AIDS, including drug discovery, pharmacology, development of drug resistance, toxicity, and prevention of mother-to-child transmission of HIV/AIDS. The authors synthesize our current understanding of the role of reverse transcriptase in the viral life cycle, describe the discovery and development of eight nucleoside and nucleotide analogs that represent milestones in treatment history, and thoroughly discuss the question of toxicity and resistance to this class of drugs. They also address three non-nucleoside RTIs and their pharmacokinetics and comparative clinical efficacy, new RTIs currently under development, and the impact of approved agents on treatment, in general, and on vertical transmission in the developing world.
Title:Reverse Transcriptase Inhibitors in HIV/AIDS TherapyFormat:PaperbackDimensions:542 pages, 9.02 × 5.98 × 0.07 inPublished:November 19, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617376957

ISBN - 13:9781617376955

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Table of Contents

Structural Studies on HIV Reverse Transcriptase Related to Drug DiscoveryDavid K. Stammers and Jingshan RenZidovudine, Lamivudine, and AbacavirMonica Carten and Harold KesslerStavudine, Didanosine, and ZalcitabineGail Skowron, Sapna Chowdhry, and Michael R. StevensEmtricitabineGail Skowron, Jeffrey Bratberg, and Rudi PauwelsNucleotide AnalogsCraig J. HoesleyResistance to Nucleoside and Nucleotide Reverse Transcriptase InhibitorsNancy Shulman and Mark WintersPharmacokinetics of Reverse Transcriptase InhibitorsPatrick Hoggard, Stephen Kewn, Saye Khoo and David BackPeripheral Neuropathy Associated With Nucleoside Reverse Transcriptase Inhibitor TherapyBruce A. Cohen and Russell BarttMitochondrial Dysfunction and Nucleoside Reverse Transcriptase Inhibitor Therapy: A Pathophysiological PerspectiveWilliam LewisMitochondrial Toxicity and LipodystrophyGrace McComseyNevirapineDavid Asmuth and Richard PollardEfavirenzGraeme J. Moyle and Brian ConwayDelavirdineBrian ConwayResistance to Non-Nucleoside Reverse Transcriptase InhibitorsF. Ramzi Asfour and Richard HaubrichVertical Transmission of HIV and Therapeutic InterventionsSusan Cu-Uvin, Arlene Bardeguez, and Carla ChibweshaNew Reverse Transcriptase Inhibitors in DevelopmentRudi PauwelsAntiretroviral Drugs for MillionsAllan Ronald, Elly Katabira, and Merle SandePostscriptRichard Ogden and Gail SkowronIndex

Editorial Reviews

From the reviews:"This book will appeal to medical students needing a detailed review of area . . It is most suitable for libraries . . The individual chapters are authoritative and comprehensive . . a source for in-depth and specific information." (Mark Harris, Microbiology Today, November, 2006)