Ribonucleases: Structures and Functions

Other | February 1, 1997

byD'Alessio, Giuseppe, Giuseppe D'Alessio

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Pancreatic ribonuclease, the focus of highly productive scientific research for more than half a century and the only enzyme to be the basis of four Nobel prizes, has recently undergone a resurgence in popularity for the recognition of an extended ribonuclease superfamily with functions ranging from tumour growth and inhibition to self-recognition and neurotoxicity. This volume highlights the functional diversity of ribonucleases and reveals the emerging research opportunities provided by these enzymes.


* Never before has discussion of the entire family of ribonucleases and related enzymes been covered in a single volume
* Core chapters focus on the latest structures and functions of pancreatic-type ribonucleases
* Structures and functions of intracellular ribonucleases and nondigestive members of the family are also covered
* How ribonucleases continue to serve as excellent systems with which to uncover the secrets of protein chemistry is demonstrated

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From the Publisher

Pancreatic ribonuclease, the focus of highly productive scientific research for more than half a century and the only enzyme to be the basis of four Nobel prizes, has recently undergone a resurgence in popularity for the recognition of an extended ribonuclease superfamily with functions ranging from tumour growth and inhibition to self...

Format:OtherDimensions:670 pages, 1 × 1 × 1 inPublished:February 1, 1997Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0080540597

ISBN - 13:9780080540597

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Table of Contents

Escherichia Coli Ribonucleases: Paradigms for Understanding Cellular RNA Metabolism and Regulation. Barstar and Barnase. Rnase T1/Rnase T2 Family Rnases. Structures and Mechanism of Action of Cytotoxic Ribonuclease I-Sarcin. Plant Ribonucleases. S-Rnases and Other Plant Extracellular Ribonucleases. Evolutionary Reconstructions in the Ribonuclease Family. Evolution of Vertebrate Ribonucleases: Ribonuclease a Superfamily. Pancreatic Ribonucleases. Crystallographic Studies of Ribonuclease Complexes. NMR Solution Structures of Ribonuclease a and Its Complexes with Mono- And Dinucleotides. Seminal Ribonuclease: The Importance of Diversity. Eosinophil-Associated Ribonucleases. Structure and Function of Angiogenin. Antitumor Rnases. 2-5A-Dependent Rnase L: A Regulated Endoribonuclease in the Interferon System. RNA Processing Rnases in Mammalian Cells. Messenger RNA Ribonucleases and Mrna Turnover in Saccharomyces Cerevisae. Ribonuclease Inhibitor. Subject Index.