Ribosomes by Alexander SpirinRibosomes by Alexander Spirin


byAlexander Spirin

Paperback | March 23, 2000

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This book is based on an advanced course of lectures on ribosome structure and protein biosynthesis that I offer at the Moscow State University. These lectures have been part of a general course on molecular biology for almost three decades, and they have undergone considerable evolution as knowledge has been pro­ gressing in this field. The progress continues, and readers should be prepared that some facts, statements, and ideas included in the book may be incomplete or out­ of-date. In any case, this is primarily a textbook, but not a comprehensive review. It provides a background of knowledge and current ideas in the field and gives ex­ amples of observations and their interpretations. I understand that some interpre­ tations and generalizations may be tentative or disputable, but I hope that this will stimulate thinking and discussing better than if I left white spots. The book has a prototype: it is my monograph "Ribosome Structure and Pro­ tein Biosynthesis" published by the Benjamin/Cummings Publishing Company, Menlo Park, California, in 1986. Here I have basically kept the former order of pre­ sentation ofthe topics and the subdivision into chapters. The contents ofthe chap­ ters, however, have been significantly revised and supplemented. The newly writ­ ten chapters on translational control in prokaryotes (Chapter 16) and eukaryotes (Chapter 17) are added.
Title:RibosomesFormat:PaperbackPublished:March 23, 2000Publisher:Springer USLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0306461463

ISBN - 13:9780306461460

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Table of Contents

I Historical and Fundamental Introduction.- 1 Protein Biosynthesis: Summary and Definitions.- 2 Messenger RNA and the Genetic Code.- 3 Transfer RNA and Aminoacyl-tRNA Synthetases.- 4 Ribosomes and Translation.- II Structure of the Ribosome.- 5 Morphology of the Ribosome.- 6 Ribosomal RNA.- 7 Ribosomal Proteins.- 8 Mutual Arrangement of Ribosomal RNA and Proteins (Quaternary Structure).- III Function of the Ribosome.- 9 Functional Activities and Functional Sites of the Ribosome.- 10 Elongation Cycle, Step I: Aminoacyl-tRNA Binding.- 11 Elongation Cycle, Step II: Transpeptidation (Peptide Bond Formation).- 12 Elongation Cycle, Step III: Translocation.- 13 Elongation Rate and Its Modulation.- 14 Termination of Translation.- 15 Initiation of Translation.- 16 Translational Control in Prokaryotes.- 17 Translational Control in Eukaryotes.- 18 Cotranslational Folding and Transmembrane Transport of Proteins.- 19 Conclusion: General Principles of Ribosome Structure and Function.