Safety and Efficacy of Non-Prescription (OTC) Analgesics and NSAIDs: Proceedings of the International Conference held at The South San Francisco Confe by K. D. RainsfordSafety and Efficacy of Non-Prescription (OTC) Analgesics and NSAIDs: Proceedings of the International Conference held at The South San Francisco Confe by K. D. Rainsford

Safety and Efficacy of Non-Prescription (OTC) Analgesics and NSAIDs: Proceedings of the…

byK. D. RainsfordEditorMichael Powanda

Paperback | October 4, 2012

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The availability of analgesics and non-steroidal anti-inflammatory drugs (NSAIDs) sold over the counter (OTC) to the public without prescription has become an issue of major concern in recent years. The problem has been highlighted in the UK, USA and other countries because of the continuing high rates of cases of poisoning and the concern over the switch for many NSAIDs from prescription-only status to OTC sale, brought about, in large part, by governments and health maintenance organisations (especially in the USA) anxious to save on the costs of these drugs. This Symposium, held at the South San Francisco Conference Center (USA) on March 17, 1997, enabled leading authorities from around the world to come together and discuss the central issues concerning the safety and efficacy of OTC analgesics and NSAIDs at what was a timely period, for the reasons outlined above. The conference opened with a series of presentations on the central themes - overall safety evaluation and assessment of the current status, the clinico-epidemiological evidence of adverse drug reactions from different drugs, pharmacokinetic and pharmacotoxicological mechanisms, and the expanding use of the drugs for pain and other states. Particular interest was addressed to the potential for NSAIDs to be used prophylactically to prevent certain chronic inflammatory/degenerative diseases (e.g. Alzheimer's and related dementias, colon cancer). The extensive debate which followed the formal presentations, summarized in the book, was exciting for enabling the core issues to be examined and assessed by experts who have been at the cutting edge of regulatory, medical and scientific evaluations of OTC analgesics/NSAIDs. Audience: General physicians, rheumatologists, pharmacologists, health policy makers.
Title:Safety and Efficacy of Non-Prescription (OTC) Analgesics and NSAIDs: Proceedings of the…Format:PaperbackDimensions:150 pages, 23.5 × 15.5 × 0.07 inPublished:October 4, 2012Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:9401060444

ISBN - 13:9789401060448

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Table of Contents

Preface. 1. Current Status of Issues Concerning the Safety of Over-the-Counter Analgesics and Non-Steroidal Anti-Inflammatory Drugs; F. Prescott. 2. Review of Published Clinical Trial Data on the Adverse Reactions from Ibuprofen and Paracetamol/Acetaminophen at OTC Dosages; K.D. Rainsford. 3. Adverse Drug Reactions in the Gastrointestinal System Attributed to Ibuprofen; D.A. Henry, et al. 4. Epidemiology of Non-Gastrointestinal Adverse Reactions from OTC Analgesics/NSAIDs; K. Jones, L. Miwa. 5. Renal Safety of Ibuprofen: Pharmacokinetic Aspects; D. Brater. 6. Therapeutic Considerations from Pharmacokinetics and Metabolism: Ibuprofen and Paracetamol; G.G. Graham, et al. 7. Acute Human Toxicity from NSAIDs and Analgesics; G.N. Volans, R. Fitzpatrick. 8. Regulatory Considerations Concerning Safety of OTC NSAIDs and Analgesics; G.E. Ehrlich. 9. Evaluation of OTC Analgesic Mechanisms and NSAIDs for Acute Pain Using the Oral Surgery Model; R.A. Dionne. 10. Multicentre Study of the Efficacy of Ibuprofen Compared with Paracetamol in Throat Pain Associated with Tonsillitis; F. Boureau. 11. Ibuprofen plus Caffeine in the Treatment of Migraine; W.F. Stewart, R.B. Lipton. Debate: Safety and Efficacy Issues with OTC NSAIDs/Analgesics. Index.