Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy by Benjamin BonavidaSensitization of Cancer Cells for Chemo/Immuno/Radio-therapy by Benjamin Bonavida

Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy

byBenjamin Bonavida

Paperback | November 19, 2010

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Cancer chemotherapy can be traced back to the 1940's and since then the world has witnessed the discovery and the important application of several new drugs. The successes of combination chemotherapy suggested that all cancers can be treated provided that the correct combination of drugs at the correct doses and correct intervals are established. However, with time, tumor cells develop mechanisms of resistance to apoptosis and no longer respond to the majority of cytotoxic therapies. Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy, edited by Benjamin Bonavida, reviews novel approaches developed to reverse tumor cell resistance to chemo/immuno/radio-therapy and the use of various sensitizing agents in combination with various cytotoxics. Such sensitizing agents target gene products that regulate resistance and therefore identify novel targets for drug development. This book also introduces several of the current approaches that have been developed by established investigators in the field that are aimed at overcoming resistance. This book is the first that compiles studies on tumor cell sensitization and is useful for students, scientists, clinicians and pharmaceutical companies.

Title:Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapyFormat:PaperbackDimensions:420 pagesPublished:November 19, 2010Publisher:Springer NatureLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:161737928X

ISBN - 13:9781617379284

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Table of Contents

Table of ContentsPrefacePart I. Sensitization via membrane-bound receptors1. Sensitization of epithelial cancer cells with human monoclonal antibodiesPeter Vollmers and Stephanie Brandlein2. Targeting the transferrin receptor to overcome resistance to anti-cancer agentsTracy R. Daniels, Isabel I. Neacato, Gustavo Helguera, Manuel L. Penichet3. Chemo-immunosensitization of resistant B-NHL as a result of rituximab (anti CD20 mAb)-mediated inhibition of cell survival signaling pathwaysBenjamin Bonavida, Ali R. Jazirehi, Mario I. Vega, Sara Huerta-Yepez, Kazuo Umezawa, and Eriko Suzuki4. Agents that regulate DR5 and sensitivity to TRAILTatsushi Yoshida and Toshiyuki Sakai5. Proteasome inhibition: Potential for sensitization of immune effector mechanisms in cancerMilad Motarjemi, William H.D. Hallett, Minghui Li, and William J. MurphyPart II. Sensitization via inhibition of cell survival pathways (excluding apoptotic signaling pathways)6. Angiogenesis inhibitors as chemosensitizing agents for the treatment of metastatic diseaseGiulio Francia, Urban Emmenegger, and Robert S. Kerbel.7. Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK and P13K/Akt pathways to sensitize cancer cells to therapyJames A. McCubrey, Richard A. Franklin, Fred E. Bertrand, Jackson R. Taylor, illiam H. Chappell, Melissa L. Midgett, Ellis WT. Wong, Stephen L. Abrams, ristin M. Stadelman, Negin Misaghian, Dale E. Lugwid, Jorg Basecke, Massimo ibra, Franca Stivala, Michele Milella, Agostino Tafuri, Alberto M. Martelli, aolo Lungi, Antonio Bonati, David M. Terrian, Brian D. Lehmann, and Linda S. Steelman8. Histone deacetylase inhibitors and anti-cancer activityRoberto R. Rosato and Steven Grant9. Eicosanoids and resistance of cancer cells to chemotherapeutic agents Andrey SorokinPart III. Sensitization via transcription factors 10. The RKIP and STAT3 axis in cancer chemotherapy: opposites attractDevasis Chatterjee, Edmond Sabo, Murray B. Resnick, Kam C. Yeung, and Y. Eugene Chin11. Targeting transcription factors with decoy oligonucelotides: modulation of the expression of genes involved in chemotherapy resistance of tumor cellsRoberto Gambari12. p53 inhibitors as cancer sensitizing agentsFlavio Maina and Rosanna Dono13. Nitric Oxide-Induced Immunosensitization to Apoptosis by Fas-L and TRAILBenjamin Bonavida, Sara Huerta-Yepez, Mario I. Vega, Demetrios A. Spandidos and Stravoula Baritaki14. Natural agents that can sensitize tumor cells to chemotherapy and radiation therapyGanesh Jagetia, Sunil Krishnan, and Bharat B. AggarwalPart IV. Sensitization via targeting apoptotic pathways15. Inhibitors of the Bcl-2 protein family as sensitizers to anticancer agentsDaniel E. Johnson16. Therapeutic targeting of apoptosis in cancerTimothy R. Wilson, Daniel B. Longley, and Patrick G. Johnston17. Peptides and peptidomimetics as cancer therapy sensitizing agentsShantanu Banerji, Sudharsana Rao Ande, Subbareddy Maddika, Versha Banerji, Iran Rashedi, Neil W. Owens, Anne Zuse, Frank Schweizer, and Marek Los18. Nonpeptidic mimetics as cancer sensitizing agentsRuud P.M. Dings, Mark Klein, and Kevin H. Mayo19. Sensitization of cancer cells to cancer therapies by isoflavone and its synthetic derivativesFazlul H. Sarkar and Yiwei Li20. Antisense oligonucelotides and siRNA as specific inhibitors of gene expression: mechanisms of action and therapeutic potentitial; AS-ODN and siRNA: mechanisms and therapeutic potentialYvonne Förster and Bernd SchwenzerPart V. Sensitization tailored to individual patients21. DNA

Editorial Reviews

From the reviews:"This book introduces emerging strategies, potential signaling pathways and biomolecules as key targets to sensitize resistant cancers. . detailed information and data can be obtained from the references listed at the end of each chapter. This book helps chemists to enrich their biological insight, and biologists to acquire new chemical strategies in reversing cancer resistance. . the book is also recommended to students in these fields. For scientists in industry and academia, and clinicians, this book provides an overview of current approaches . ." (Yoshihiko Kotake, ChemMedChem, Vol. 4, 2009)