Sickle Cell Disease by Graham SerjeantSickle Cell Disease by Graham Serjeant

Sickle Cell Disease

byGraham Serjeant

Hardcover | April 1, 2001

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Sickle cell disease is one of the 'grand' diseases in the terminology of Victorian pathology, because its widespread and multitudinous manifestations may affect any organ system in the body. It has served as a model of molecular disease being one of the first genetic disorders to be explainedat the molecular level. Since publication of the Second Edition, however, further advances have been made. Much has been learnt about the causes of variability in the natural history of the disease and of the reasons why there are such marked variations in the patterns of morbidity and mortality.As Director of The Jamaican Sickle Cell Unit, Graham Serjeant and his colleagues have shown the disease to be extremely variable ranging from a severe clinical course with death in early childhood to mildly affected patients living to the age of 80 years. This extreme variability within a singlegenotype implies that other factors, both genetic and environmental, must influence expression of the disease. This new edition contains many new references and incorporates the latest thinking on the biology of the disease and the best practice in its management.
Graham R Serjeant , Director, Medical Research Council Laboratories (Jamaica), University of the West Indies, Kingston, Jamaica
Title:Sickle Cell DiseaseFormat:HardcoverDimensions:772 pagesPublished:April 1, 2001Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0192630369

ISBN - 13:9780192630360


Table of Contents

Part 1 General aspects1. Basic concepts2. Distribution of sickle cell disease3. Nomenclature and genetics of sickle cell disease4. Diagnosis of sickle cell disease5. Pathophysiology of sickle cell disease6. Historical aspectsPart 2 System review7. The bone marrow8. The blood9. The liver10. The spleen11. The immune system12. The gut and abdomen13. Cardiovascular system14. Pulmonary system15. Leg ulceration16. Bone and joint lesions17. The painful crisis18. Renal manifestations19. Priapism20. The nervous system21. The eyes22. Phyical and sexual development23. Pregnancy and contraception24. Endocrine system, metabolism, and nutritionPart 3 Comparison of sickle cell syndromes25. Homozygous sickle cell disease26. Sickle cell-haemoglobin C disease27. Sickle cell - ss thalassaemia28. Other forms of sickle cell disease29. Sickle cell - hereditary persistence of fetal haemoglobin30. The sickle cell traitPart 4 Management31. General supportive measures32. Transfusion33. Attempts to inhibit sickling34. Surgery and anaesthesia35. Screening and sickle cell clinicsPart 5 Epidemiology36. Age and patterns of clinical involvement37. Causes of death38. Natural historyReferencesIndex