Signal Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and Medicine by Rui WangSignal Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and Medicine by Rui Wang

Signal Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and Medicine

EditorRui Wang

Paperback | November 5, 2010

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Distinguished researchers and clinicians review the biological and biomedical aspects of gasotransmitters, emphasizing signaling transduction mechanisms in general, and ion channel regulation in particular. The authors discuss the endogeneous metabolism and regulation of gasotransmitters, their toxicological profiles and biological actions, and their interactions in terms of their production and effects. The physiological roles of NO, CO, and H2S in the regulation of the cardiovascular, neuronal, and gastrointestinal systems, as well as of cell metabolism, are also reviewed, along with the interaction of the gastrotransmitters with KATP,KCa voltage-gated Ca2+, voltage-gated Na+, and cyclic nucleotide-gated ion channels.
Title:Signal Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and MedicineFormat:PaperbackDimensions:391 pages, 10 × 7.01 × 0 inPublished:November 5, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617375128

ISBN - 13:9781617375125

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Table of Contents

Part I. Gasotransmitters: Past, Present, and FutureThe Evolution of Gasotransmitter Biology and Medicine: From Atmospheric Toxic Gases to Endogenous Gaseous Signaling MoleculesRui WangInteractions Between GasotransmittersRay J. Carson, Gunter Seyffarth, Rubina Mian, and Helen MaddockPart II. The Emergence of the First Gasotransmitter: Nitric OxideNitric Oxide: Synthesis and Metabolism, Tissue Stores, and the Relationship of Endothelium-Derived Nitric Oxide to Endothelium-Dependent HyperpolarizationChris R. Triggle, Hong Ding, Ella S. M. Ng, and Anthie EllisChemical Interaction of Nitric Oxide With Protein Thiols: S-Nitrosylation SignalingAllan Doctor and Benjamin M. GastonNitric Oxide and Adenosine Triphosphate-Sensitive Potassium Channels: Their Different Properties But Analogous Effects on Cellular ProtectionShoji Sanada, Jiyoong Kim, and Masafumi KitakazeInteractions of Nitric Oxide and Related Radical Species With KCa ChannelsYanping Liu and David D. GuttermanNitric Oxide and Voltage-Gated Ca2+ ChannelsClaudio Grassi, Marcello D'Ascenzo, and Gian Battista AzzenaInteractions of Nitric Oxide and Cardiac Ion ChannelsZhao Zhang, Kathryn A. Glatter, and Nipavan ChiamvimonvatS-Nitrosylation of Cyclic Nucleotide-Gated ChannelsMarie-Christine BroilletPart III. Story of a Silent Killer: The Resurgence of Carbon Monoxide as the Second GasotransmitterSynthesis and Metabolism of Carbon MonoxideStefan W. Ryter and Augustine M. K. ChoiInteraction of Carbon Monoxide With K+ Channels in Vascular Smooth Muscle CellsRui WangModulation of Multiple Types of Ion Channels by Carbon Monoxide in Nonvascular Tissues and CellsRui WangThe Molecular Mechanisms Underlying the Effects of Carbon Monoxide on Calcium-Activated K+ ChannelsLingyun WuCarbon Monoxide and Signal Transduction PathwaysPatty J. Lee and Leo E. OtterbeinCarbon Monoxide-Induced Alterations in the Expression of KCa Channels in Pulmonary Artery Smooth Muscle CellsEric Dubuis, Prem Kumar, Pierre Bonnet, and Christophe VandierPart IV. Gas of the Rotten Egg: Hydrogen Sulfide as Another GasotransmitterHydrogen Sulfide Production and Metabolism in Mammalian TissuesKenneth N. Maclean and Jan P. KrausToxicological and Environmental Impacts of Hydrogen SulfideSheldon H. RothHydrogen Sulfide and the Regulation of Neuronal ActivitiesHideo KimuraThe Role of Hydrogen Sulfide as an Endogenous Vasorelaxant FactorRui Wang, Youqin Cheng, and Lingyun WuHydrogen Sulfide and Visceral Smooth Muscle ContractilityPhilip K. MooreInteraction of Hydrogen Sulfide and Adenosine Triphosphate-Sensitive Potassium Channels in Vascular Smooth Muscle CellsRui WangPart V. Gasotransmitters, Other Gaseous Molecules, and Cell MetabolismGasotransmitters as a Novel Class of Metabolic Regulators: Nitric Oxide, Carbon Monoxide, and Nitrous OxideMisato KashibaIndex

Editorial Reviews

From the foreword..."...a paradigm-shifting assessment of the new category of transmitters, the gasotransmitters." -Bruce McManus, MD, PhD, FRSC, Canadian Institutes of Health Research"...well-written...the account by Sanada and colleagues is particularly interesting on cardio protection and ischeamic preconditioning...this book should be of interest to both specialist researchers as well as members of the wider scientific commuity." -BTS Newsletters"...an excellent source of references for signal transduction mechanisms underlying he physiological functions of NO, CO, and H2S." - British Journal of Anesthesiology