Sirtuins by Riekelt H. HoutkooperSirtuins by Riekelt H. Houtkooper


byRiekelt H. Houtkooper

Hardcover | November 25, 2016

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The sirtuin family of proteins (SIRT1-7) received a lot of attention in recent years as they serve as metabolic sensors that control not only metabolism, but also aging and lifespan regulation. As such, sirtuins are strong targets for the treatment of age-related metabolic diseases, including obesity, diabetes, and cancer. Indeed, many research groups as well as pharmaceutical companies discovered food components and/or drugs that target the sirtuins and provide significant health benefits. This book focuses on various aspects of sirtuin biology, from basic biochemistry, via molecular function, to its role in (fighting) human disease.
Title:SirtuinsFormat:HardcoverDimensions:288 pagesPublished:November 25, 2016Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:9402409610

ISBN - 13:9789402409611

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Table of Contents

General introduction
Riekelt H. Houtkooper

Biochemistry and Enzymology of Sirtuins
Yue Yang and Anthony A. Sauve

NAD+ as a pharmacological tool to boost sirtuin activity
Riekelt H. Houtkooper

Protein lysine acylation: abundance, dynamics and function
Olga Pougovkina and Vincent C. J. de Boer

SIRT1 in metabolic health and disease
Marie Boutant and Carles Cantó

Deacetylation by SIRT3 relieves inhibition of mitochondrial protein function 
Peter Chhoy, Kristin A. Anderson, Kathleen A. Hershberger, Frank K. Huynh, Angelical S. Martin, Eoin McDonnell, Brett S. Peterson, Laura A. Starzenski, Donald S. Backos, Kristofer S. Fritz, and Matthew D. Hirschey

SIRT5 reveals novel enzymatic activities of sirtuins
Bin He and Hening Lin

Diverse roles for SIRT6 in mammalian healthspan and longevity
Bernadette M. M. Zwaans, William Giblin and David B. Lombard

Sirtuins in cancer - emerging role as modulators of metabolic reprogramming
Jaewon J. Lee, Karina N. Gonzalez Herrera and Marcia C. Haigis

Sirtuins as metabolic modulators of muscle plasticity
Keir Menzies, Julien Francisco Zaldivar-Jolissaint and Johan Auwerx

Sirtuins and aging
Carles Cantó and Riekelt Houtkooper

Sirtuins and the Circadian Clock: Epigenetic and Metabolic Crosstalk 
Selma Masri, Marina Maria Bellet and Paolo Sassone-Corsi

Sirtuin activation by small molecules
Hassina Massudi, Lindsay E. Wu, and David A. Sinclair

Future perspective
Brian Kennedy