Sjogren's Syndrome: Clinical and Immunological Aspects by Norman TalalSjogren's Syndrome: Clinical and Immunological Aspects by Norman Talal

Sjogren's Syndrome: Clinical and Immunological Aspects

byNorman TalalEditorHaralampos M. Moutsopoulos, Stuart S. Kassan

Paperback | May 19, 2012

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I have been a student of Sjogren's syndrome for virtually all of my professional life. My education in this disease began in 1962 when I arrived at the National Institutes of Health to begin a Clinical Asso­ ciateship with Dr. Joseph J. Bunim. Bunim introduced me to a pat­ ient with Sjogren's syndrome of 8 years duration who had devel­ oped malignant lymphoma 6 months previously. He told me that there were other such patients. I obtained serum samples from these patients and studied them by the then new technique of immuno­ electrophoresis. We observed that an initial hypergammaglobulin­ emia could progressively decline to hypogammaglobulinemia with loss of autoantibodies. One patient in this initial series had macrog­ lobulinemia. We published this report and suggested that the auto­ immunity predisposed to the malignant transformation. Thus began my love affair with this disease. In those days many rheumatologists considered Sjogren's syn­ drome simply a variant of rheumatoid arthritis. It's curious that two decades ago there was little confusion between Sjogren's syndrome and systemic lupus erythematosus, whereas today there is great con­ fusion. There is still a great need for internationally agreed upon di­ agnostic criteria, which merely illustrates once again the difficulty of accurate diagnosis in our profession. The multidisciplinary aspects of Sjogren's syndrome require au­ thorities in several areas of medicine. The various chapter contribu­ tors are experts in their field and have often put aside other respon­ sibilities to complete their contributions and not delay publication.
Title:Sjogren's Syndrome: Clinical and Immunological AspectsFormat:PaperbackDimensions:300 pages, 24.4 × 17 × 0.01 inPublished:May 19, 2012Publisher:Springer NatureLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3642501206

ISBN - 13:9783642501203

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Table of Contents

I. Introduction.- 1. Historical Perspective: The Early Years (1930-1960).- 2. The Patient's Perspective.- II. Clinical Spectrum.- A. Glandular Findings.- 1. Oral Manifestations of Sjögren's Syndrome.- 2. The Eye in Sjögren's Syndrome.- 3. Chemistry of Saliva.- 4. Histopathology of Sjögren's Syndrome.- B. Extraglandular Findings.- 1. Primary Sjögren's Syndrome in the People's Republic of China.- 2. Neuromuscular Complications of Primary Sjögren's Syndrome.- 3. The Respiratory System in Sjögren's Syndrome.- 4. Gastrointestinal and Hepatobiliary Features in Sjögren's Syndrome.- 5. Renal Disease with Sjögren's Syndrome.- 6. Inflammatory Vascular Disease in Sjögren's Syndrome.- C. Lymphoid Malignancy.- 1. Lymphoid Malignancy and Monoclonal Proteins.- 2. Detection of Lymphoma in Sjögren's Syndrome by Analysis of Immunoglobulin Gene Rearrangements.- 3. Lymphoproliferative Disorders in Japanese Patients with Sjögren's Syndrome.- D. Relationship to Other Autoimmune Diseases.- 1. Relationship of Sjögren's Syndrome to Rheumatoid Arthritis.- 2. Sjögren's Syndrome with Systemic Lupus Erythematosus/Mixed Connective Tissue Disease.- 3. Sjögren's Syndrome and Systemic Sclerosis (Scleroderma).- E. Diagnosis and Differential Diagnosis.- 1. Diagnosis and Differential Diagnosis of Sjögren's Syndrome.- III. Laboratory Abnormalities.- 1. Rheumatoid Factor in Sjögren's Syndrome.- 2. Autoantibodies in Sjögren's Syndrome.- 3. Immunogenetics of Sjögren's Syndrome.- 4. The Relationship Between Anti-RO(SS-A) Precipitin Antibody Positive Sjögren's Syndrome and Anti-RO(SS-A) Precipitin Antibody Positive Lupus Erythematosus.- 5. Immunologic Abnormalities in Sjögren's Syndrome.- 6. Animal Models of Sjögren's Syndrome.- IV. Treatment of Sjögren's Syndrome.