Small Animal Imaging: Basics and Practical Guide by Fabian KiesslingSmall Animal Imaging: Basics and Practical Guide by Fabian Kiessling

Small Animal Imaging: Basics and Practical Guide

EditorFabian Kiessling, Bernd J. Pichler

Hardcover | December 16, 2010

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Small animal imaging has been recognized as an important tool in preclinical research. Nevertheless, the results of non-invasive imaging are often disappointing owing to choice of a suboptimal imaging modality and/or shortcomings in study design, experimental setup, and data evaluation. This textbook is a practical guide to the use of non-invasive imaging in preclinical research. Each of the available imaging modalities is discussed in detail, with the assistance of numerous informative illustrations. In addition, many useful hints are provided on the installation of a small animal unit, study planning, animal handling, and the cost-effective performance of small animal imaging. Cross-calibration methods, data postprocessing, and special imaging applications are also considered in depth. This is the first book to cover all the practical basics in small animal imaging, and it will prove an invaluable aid for researchers, students, and technicians.
Since 2008 Professor Dr. Fabian Kiessling is leading the Institute of Experimental Molecular Imaging at the Helmholtz Center of Applied Engineering of the RWTH-University in Aachen. Aim of his research is the development of novel diagnostic probes and imaging tools for a disease specific diagnosis and therapy monitoring. In this contex...
Title:Small Animal Imaging: Basics and Practical GuideFormat:HardcoverDimensions:614 pagesPublished:December 16, 2010Publisher:Springer Berlin HeidelbergLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3642129447

ISBN - 13:9783642129445

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Table of Contents

1.Preamble 2.Role of small animal imaging: Non invasive imaging for supporting basic research.-Non invasive imaging in the pharmaceutical industry.-How to set up a small animal imaging unit.-Significance of non invasive imaging for animal protection3.Study planning and animal preparation: Institutional preconditions for small animal imaging.-Statistical considerations for animal imaging studies.-Animal anesthesia and monitoring.-Drug administration4.Imaging modalities and probes: How to choose the right imaging modality.-X-ray and X-ray-CT.-CT contrast agents.-MRI.-MR contrast agents.-MRS.-Ultrasound.-Ultrasound contrast agents.-PET and SPECT.-Radiotracer.-Optical imaging.-Optical probes.-Multimodal imaging and image fusion5.Ex vivo validation methods:Ex vivo and in vitro cross calibration methods.-In Vitro Methods for In Vivo Quantitation of PET and SPECT Imaging Probes: Autoradiography and Gamma Counting6.Data postprocessing: Qualitative and quantitative data analysis.-Guidelines for nuclear image analysis.-Kinetic modeling.-Data documentation systems 7.Special applications: Imaging in developmental biology.-Imaging in gynecology research.-Imaging in cardiovascular research.-Imaging in neurology research.-Imaging in oncology research.-Imaging in immunology research8.Tables: Relevant physiological standard parameters of rodents

Editorial Reviews

From the reviews:"This text is a guide to implement small animal imaging in routine research. . this book of significant value to a large series of readers, including both expert nuclear physicians and radiologists and residents involved in diagnostic imaging, for whom it can serve as a reference book in daily work or as cultural background. The publication may also be of great interest for all scientists working in basic and translational research." (Adriano Anzivino and Luigi Mansi, European Journal of Nuclear Medicine and Molecular Imaging, Vol. 39, 2012)