Spotlight On Familial And Hereditary Gastric Cancer by Giovanni CorsoSpotlight On Familial And Hereditary Gastric Cancer by Giovanni Corso

Spotlight On Familial And Hereditary Gastric Cancer

byGiovanni CorsoEditorFranco Roviello

Paperback | July 15, 2015

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In this book we have taken a comprehensive look at the subject of familial and hereditary gastric tumors. In particular, the aim of this novel editorial work is to propose the correct management of hereditary diffuse gastric cancer patients, focusing in particular on E-cadherin germline mutations, clinical criteria definition, genetic screening and molecular mechanisms, pathology and microscopic features, surgical treatment and clinical approach for asymptomatic mutation carriers. We also describe other inherited predispositions involving gastric carcinoma.
Title:Spotlight On Familial And Hereditary Gastric CancerFormat:PaperbackDimensions:211 pages, 23.5 × 15.5 × 0.02 inPublished:July 15, 2015Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:940079715X

ISBN - 13:9789400797154

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Table of Contents

Foreword(Herny T. Lynch).Preface.Section I - General Issues. 1. Historical overview of familial gastric cancer. 2. Frequency of familial gastric cancer. 3. The family cancer database. Section II - Genetics and Epigenetics. 4.CDH1gene, structure and function. 5. E-cadherin germline mutation. 6. Molecular mechanisms of hereditary diffuse gastric cancer initiation and progression. 7. Germline missense mutants in hereditary diffuse gastric cancer. 8. Alternative mechanisms to germlineCDH1mutations in hereditary diffuse gastric cancer. 9. BeyondCDH1mutation-causes of hereditary gastric cancer. 10. Non-CDH1-associated familial gastric cancer and epigenetics factors. Section III - Pathology. 11.Hereditary diffuse gastric cancer and lobular breast carcinoma. 12. Pathology of hereditary diffuse gastric cancer. Section IV - Management. 13. Clinical criteria for familial gastric cancer definition. 14. Prophylactic total gastrectomy inCDH1germline mutation carrier. 15. Gastric cancer in other inherited syndromes.16.Clinical management of familial gastric cancer. Appendix. Index.