Statistical Theory and Methods for Evolutionary Genomics

Hardcover | May 11, 2010

byXun Gu

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Evolutionary genomics is a relatively new research field with the ultimate goal of understanding the underlying evolutionary and genetic mechanisms for the emergence of genome complexity under changing environments. It stems from an integration of high throughput data from functional genomics,statistical modelling and bioinformatics, and the procedure of phylogeny-based analysis. Statistical Theory and Methods for Evolutionary Genomics summarises the statistical framework of evolutionary genomics, and illustrates how statistical modelling and testing can enhance our understanding of functional genomic evolution. The book reviews the recent developments in methodology from anevolutionary perspective of genome function, and incorporates substantial examples from high throughput data in model organisms. In addition to phylogeny-based functional analysis of DNA sequences, the author includes extensive discussion on how new types of functional genomic data (e.g. microarray)can provide exciting new insights into the evolution of genome function, which can lead in turn to an understanding of the emergence of genome complexity during evolution.

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From the Publisher

Evolutionary genomics is a relatively new research field with the ultimate goal of understanding the underlying evolutionary and genetic mechanisms for the emergence of genome complexity under changing environments. It stems from an integration of high throughput data from functional genomics,statistical modelling and bioinformatics, a...

Xun Gu obtained his Ph.D from the University of Texas in 1996 and is now Professor in the Department of Genetics, Development and Cell Biology at Iowa State University. His research has been focused on statistical and computational methods for understanding genome complexity and evolution, and high throughput comparative genomics anal...
Format:HardcoverDimensions:220 pagesPublished:May 11, 2010Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199213267

ISBN - 13:9780199213269

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Table of Contents

Preface1. Basics in Molecular Evolution2. Basics in Bioinformatics and Statistics3. Functional Divergence after Gene Duplication: Statistical Modeling4. Functional Divergence after Gene Duplication: Applications and Others5. Phylogenomic Expression Analysis between Duplicate Genes6. Expression between Duplicate Genes: Genome-Wide Analysis7. Tissue-Driven Hypothesis of Genomic Evolution8. Gene Pleiotropy and Evolution of Protein Sequence9. Modeling the Genomic Evolution of Gene Contents10. Advanced Topics in Systems Biology and Network EvolutionReferencesIndex