Stem Cells and Myocardial Regeneration by Marc S. PennStem Cells and Myocardial Regeneration by Marc S. Penn

Stem Cells and Myocardial Regeneration

EditorMarc S. Penn

Paperback | December 10, 2010

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Stem Cells and Myocardial Regeneration is a comprehensive bench to bedside examination of stem cell-based therapies for cardiac dysfunction. The contributors, all leading researchers in their area of expertise, explore recent advances in the laboratory and in clinical trials. This volume emphasizes the near epidemic status of chronic heart failure (CHF) in the United States and abroad, and evaluates the level of success and failure of current optimal medical therapy. Specific attention is also given to both the basic cell types and pathways involved in cardiac stem cell research and the clinical issues that surround it. Parts I and II of Stem Cells and Myocardial Regeneration examine various cardiac stem cell types, including hematopoietic, mesenchymal, and endogenous cells and critical physiological pathways, including chemokines, stem cell differentiation, and arrhythmia mechanisms. Part III focuses on clinical issues intrinsic to delivery of stem cells to the heart at the time of myocardial infarction (MI) and in patients with CHF. Part IV contains up-to-date reviews and analyses of the findings of stem cell-based clinical trials of acute MI and CHF. The concluding section presents a summary of cardiac stem cell research and outlines potential obstacles to future study.
Title:Stem Cells and Myocardial RegenerationFormat:PaperbackDimensions:400 pagesPublished:December 10, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617377058

ISBN - 13:9781617377051

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Table of Contents

Stem Cells and Myocardial RegenerationTable of Contents1. The Challenge for Stem Cell Therapy: Overview of the Problem: Heart Attack and Heart Failure Marc S. Penn, MD, PhD Eric J. Topol, MD Cleveland Clinic FoundationCells of interest for myocardial regeneration2. Hematopoietic Stem Cells for Myocardial Regeneration Don Orlic, PhD Richard O. Cannon III, M.D.National Institutes of Health3. Mesenchymal Stem Cells for Cardiac Therapy Mark F. Pittenger, PhDOsiris Therapeutics, Inc4. Multipotent Adult Progenitor Cells Wouter van't Hof Niladri Mal Amy Raber Ming Zhang Anthony Ting Marc S. Penn Robert DeansAthersys5. Mesenchymal Progenitor Cells for Vascular Formation and Cardiac Muscle Regeneration Silviu Itescu MD Fiona See PhD Timothy Martens MDColumbia University6. Umbilical Cord Blood Stem Cells for Myocardial Regeneration and Angiogenesis Shyam Bhakta, MD Mary Laughlin, MDCase Western Reserve University7. Endogenous Cardiac Stem Cells Elisa Messina Alessandro Giacomello Eduardo MarbanUniversity of Rome "La Sapienza" & Johns Hopkins University8. Embryonic Stem Cells for Myocardial Repair Lior Gepstein, MD, PhDTechnion, IsraelMechanisms and critical pathways involved in myocardial repair9. Chemokine and Homing Factor Expression in Acute Myocardial Infarction and Congestive Heart Failure Arman T. Askari, MD Marc S. Penn, MD, PhDCleveland Clinic Foundation10. Stem Cell Differentiation Towards a Cardiac Myocyte Phenotype Andrea Ladd, PhDCleveland Clinic Foundation11. Electrical Coupling and/or Ventricular Tachycardia Risk of Cell Therapy Shuixiang Yang MD Dayi Hu, MD, PhDBeijing, China12. Cell Therapy for Myocardial Damage: Arrhythmia Risk and Mechanisms William R. Mills, MD Kenneth R. Laurita, PhDMetroHealth Campus, Case Western Reserve UniversityStrategies for Cell Delivery advantages/disadvantages13. Aspects of Percutaneous Cellular Cardiomyoplasty Matthew Hook, MD Patrick Whitlow, MDCleveland Clinic Foundation14. Open-Chest / Minimally Invasive Surgical Techniques Roberto Lorusso MD, PhD Josè L. Navia, MD Cesare Beghi°, MD Fernando A. Atik, MDCleveland Clinic Foundation, Brescia and Parma, ItalyStem Cell Based Clinical Trials for Cardiac Dysfunction15. Measures of Effective Cell Based Therapies Wael A. Jaber, MD Manuel Cerqueira, MDCleveland Clinic FoundationCongestive Heart Failure16. Whole Bone Marrow Transplantation Emerson C. Perin, MD Guilherme V. Silva, MD Texas Heart Institute17. Clinical Angioblast Therapy Amit N. Patel, MD, MS Jorge Genovese, MDUniversity of Pittsburgh Medical Center18. Use of skeletal myoblasts for the treatment of CHF Anthony W. Ashton David D'Alessandro Robert E. MichlerAlbert Einstein CollegeAcute MI 19. Bone Marrow and Angioblast Transplantation Marc S. Penn, MD, PhD Samuel Unzek, MD Niladri Mal, MD Kai Wang, MD, PhDCleveland Clinic Foundation20. Strategies for Cytokine Modification and Stem Cell Mobilization Stephen G. Ellis, MD Brian J. Bolwell, MDCleveland Clinic FoundationSummary/Future Challenges21 Summary and Future Challenges Marc S. Penn, MD, PhDCleveland Clinic Foundation